GenomeNet

Database: UniProt
Entry: C5BHQ7_EDWI9
LinkDB: C5BHQ7_EDWI9
Original site: C5BHQ7_EDWI9 
ID   C5BHQ7_EDWI9            Unreviewed;       238 AA.
AC   C5BHQ7;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-SEP-2017, entry version 65.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00634471};
GN   Name=hda {ECO:0000256|HAMAP-Rule:MF_01158};
GN   OrderedLocusNames=NT01EI_1194 {ECO:0000313|EMBL:ACR68402.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR68402.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the interaction of DNA replication inititator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp
CC       (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering
CC       DnaA inactive for reinititation, a process called regulatory
CC       inhibition of DnaA or RIDA. {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms
CC       the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA,
CC       ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
CC       {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00548763}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP001600; ACR68402.1; -; Genomic_DNA.
DR   STRING; 634503.NT01EI_1194; -.
DR   EnsemblBacteria; ACR68402; ACR68402; NT01EI_1194.
DR   KEGG; eic:NT01EI_1194; -.
DR   eggNOG; ENOG4108KZ1; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000256538; -.
DR   KO; K10763; -.
DR   OMA; DWGQIYR; -.
DR   OrthoDB; POG091H0GIW; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IEA:InterPro.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634466};
KW   DNA replication inhibitor {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485}.
FT   DOMAIN       21    216       Bac_DnaA. {ECO:0000259|Pfam:PF00308}.
SQ   SEQUENCE   238 AA;  27036 MW;  D4F3359672CB4FBF CRC64;
     MSEVNLNTPT QLSLPLYLPD DETFSSFYAG ENAALLAALQ NALRQEHGSY IYFWSREGGG
     RSHLLHAACA ELSQRGEAVG FVPLDKRAYF VPEVLDGMEQ LALVCIDNIE CIAGDGAWEM
     AIFNLYNRIQ ESGRTRLLIT GDRPPRQLNL RLPDLASRLD WGQIYKLQPL GDEEKLQALQ
     LRARLRGFEL PEDVGRFLLK RLDREMRTLF MTLDQLDRAS IAAQRKLTIP FVKETLLL
//
DBGET integrated database retrieval system