ID C5BJI3_TERTT Unreviewed; 4663 AA.
AC C5BJI3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Modular polyketide synthase, type I PKS {ECO:0000313|EMBL:ACR13065.1};
GN OrderedLocusNames=TERTU_2204 {ECO:0000313|EMBL:ACR13065.1};
OS Teredinibacter turnerae (strain ATCC 39867 / T7901).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Cellvibrionaceae; Teredinibacter.
OX NCBI_TaxID=377629 {ECO:0000313|EMBL:ACR13065.1, ECO:0000313|Proteomes:UP000009080};
RN [1] {ECO:0000313|EMBL:ACR13065.1, ECO:0000313|Proteomes:UP000009080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39867 / T7901 {ECO:0000313|Proteomes:UP000009080};
RX PubMed=19568419; DOI=10.1371/journal.pone.0006085;
RA Yang J.C., Madupu R., Durkin A.S., Ekborg N.A., Pedamallu C.S.,
RA Hostetler J.B., Radune D., Toms B.S., Henrissat B., Coutinho P.M.,
RA Schwarz S., Field L., Trindade-Silva A.E., Soares C.A.G., Elshahawi S.,
RA Hanora A., Schmidt E.W., Haygood M.G., Posfai J., Benner J., Madinger C.,
RA Nove J., Anton B., Chaudhary K., Foster J., Holman A., Kumar S.,
RA Lessard P.A., Luyten Y.A., Slatko B., Wood N., Wu B., Teplitski M.,
RA Mougous J.D., Ward N., Eisen J.A., Badger J.H., Distel D.L.;
RT "The complete genome of Teredinibacter turnerae T7901: an intracellular
RT endosymbiont of marine wood-boring bivalves (shipworms).";
RL PLoS ONE 4:E6085-E6085(2009).
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467}.
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DR EMBL; CP001614; ACR13065.1; -; Genomic_DNA.
DR RefSeq; WP_015819178.1; NC_012997.1.
DR STRING; 377629.TERTU_2204; -.
DR KEGG; ttu:TERTU_2204; -.
DR eggNOG; COG0236; Bacteria.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG3319; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR eggNOG; COG3433; Bacteria.
DR HOGENOM; CLU_000022_58_0_6; -.
DR OrthoDB; 9808669at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000009080; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 1.10.1240.100; -; 3.
DR Gene3D; 3.10.129.120; -; 1.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 3.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009080};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 495..571
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 612..1045
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2387..2463
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2563..2976
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3184..3261
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3331..3748
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4015..4092
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2512..2531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3134..3180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3936..4013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3938..3960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3977..3994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4663 AA; 504612 MW; AF6DE401A24227B4 CRC64;
MNDKNAVLAA VKDGTLTVEQ ALVALRKLQD KMPLDQSQLA VYEPSWVDAP ATNTARSALG
LVVVNSRACL SDALGDCDVV LVDAGRYLLF ASASACTRNE TPLKEFSSLH EFTTFSREKI
TQKSGLWLVH ASAENDVEPA LLDVFAWVKS LSTLNADQSV QRWSFGATGE YAAVANEAIA
GFLRGARVEN PNCHFSVLFD FSVETDHWRE ELAAAAEHVE VRYLSSRRQV LRLVQTPELS
SQTPAWLHNK CHLIISGGGG ELALSLSRIL LEREDLCITL LGRSPAKPAV EKLIAQHSSR
VAYQQADIAD KTAVDGAICE SVRRFAGDLV LVHCAGVLAD SFINKASADQ YAKVLSPKYQ
GTINLLRAVH KYNVNSVILF SSIAAYLPHS GQSFYASANR AMTALAKKFL PSSVALQVLH
WPLWDGGGMD ISAEDKALMR SETGMVPLPQ VLGWQVLLKS GAGNRVIAFG DKAEIVRFIG
DKDAMKIRKH TPRVQSREQA QTAIIDALCD ATQFPSTKVK PKLSLQAMGL DSMIITRLNV
TLEKQFGTLP KTLLFDCHTI AELTDAILSR VEIVPQPGTS EPASIAKSSV AVQVTADQTP
QISQPHTDSV DAKAVAIIGL AGRYPAAANI DEFWQNLVEG KDSITEIPAD RWDWQAYYRP
QKTSGFSHSK WGGFLNDVDA FDPLFFAISP REAESIDPQE RLFLQTVWHT LEDAGYSPQR
LREYSRKASS RQHAVGVYVG VTSGQYQQLS AQDWGRGERT LASSAYWSIA NRVSFFLNLQ
GPSIAIDTAC SASLSAITLG YESLVAGKTK MALVGGVNIN LDPSRYVALS DMGFLSLDGR
CRSFGKGGTG FVPSEGVGAA LLKPLSAAKK DGDNVYAVIR GAAVNHSGTT NGYSVPSPQS
QALLVHDALQ DAGVNARDIS LIETHGTGTA LGDPIEVDGL TQAFRMNGGS GLRASCALSS
VKSNIGHLES AAGIAGLTKL VLQLYRRQRV PSLHADVLNP ALDLENTPFF VQTDFAPWVS
ESAPRIGGLS SFGAGGSNAH LIVEQAPGKL TKYDSSDYKN SDVTVPLAVF SANNPAGLAR
LCRAHLDFLQ AADTEFSFAC YLFSLQTSRA ALNTRIAIHT SSKDALISEL MNLLATDIHK
NTNVHKLVDE DVEDEFTAPA DNLTLNSQEL QALQEGWLSG INWRWENLWQ GTPVTRIPLP
LYPFAKMRLW YRERSFEPVP NRIDNSQVEW SIPPAASAVA DHVIQEQPIL SGMGHLSLVL
ASLKECGLVE TQLSGGYEFT DVHWLRPLAS QRKQMRVTVE VQPQNDTVQF RVKNAEGELA
SFGKFKRFGA EPSRIQKSFD DVEFSASDSW RGERLYQAMA AAGFTYGPGY QYVDQLEYSE
SQVNFELQVA PDTNDVFHPG FVDSMLQSIF VLHSQQESAP AVPFKVASIR VYEAPCRAAK
GSIRALQSTA DGEYPYQISA ASNTGKPVIE FDQFVARRIE SAPAEDPGVV TQHVNRVELN
RNAPTIFDHC YAPRWVALES QDFLTVVEPT RRHVVITSSS SSDIQNSLLQ KLSEAEGRGR
LASLAVIPIQ QLASARETLN SADTLWFTAA IYPQRYSLAD TAFVDRFLKE ALFNLLQLAK
HCFGQSNAQR LIVLTNDAFA LQPQQHNFHP LAAGLLGFTK AFAQEARQVE CYQLDLSQAL
VEQGLLPPLF ADLNRLVPVQ ARLPGCAVAN HHGEYVVEKF SRFAGAPQAT QPQIAFRDAG
VYLIIGGAGG LGLAFAKHLR EKYEARVILV GRRSAGAVAE LVSGQFDYRQ CDISDAQQVQ
LLLKTVQQEY GALHGVVHSA LTLQDTSVAK MQDEDLAAAL NAKVFGTIQL MESLTALNLD
FILFFSSTIS QTCSPGQSNY AAASLTQDAL ANYYARLHRG IRVVNWGFWH EIGVVADEFY
RQRMYAKGLL GITFDDGLSV LDALLAGTER QLVALKLNSQ GMSQWQPYLC DQAKGAQVNS
QFSGGNSNSA LHQLWQGLRP SFEHENAQLM NQYCQQRVLA ILQKRGLFVD VESALGVQEV
LNGFAAKQDS IPLVNAMLAM LARGRYLIQR GASWSLAAKL PKALERARVL QKNSQAEGHL
RLLDHCLDNL PLLLDGKKSD TEILFPGGSA HLVQATYRDN PVSDACNAMV AAAVEDEISR
LVANGVQEIN LVEIGAGTGS TTSPVAKKIS ANFNSTIKLH YWFTDLSSHF VARAKRELAT
EYPFIEAAVF DVAAADLARE QAQAGIPNCD ILLASNVLHA TDNIVYTLKN CDQLLKPSGR
MIINEVTENW DFVTMTFGLT KGWWLFEDAH LRMPHSPLLS CAQWGQALRE SGLEGRDYFG
GGPEYSSLES EALGQTVILA TASEGARATQ VSRAEQTAQA NTPSAPEADG THVAYLKSVF
ARVLKIPVAE LDEHDNFQSF GLDSIILPEV LNALQERFPA LTLEQLNQAE TIADVAKLTL
TMGAASVEVS AKAPVQNALP LNANTTGSSA RMDEKSALQT VAPQTISTLE RGQKPYSEAV
VSTPSGSDYR PQHSDTLIAT PVPTATPAPT AIPNQAGRTD ANTAEVAIIG VAGMYPGAAN
IDEFWQQLCM GTPAATPVPH NRWQSDNSEF GSFLNAVDEF DPLFFGISPR EAPQLDPQQR
VMLDVCWHLL EDAGYAPETL TGGRNNFASS VGVYVASMYQ HYGQLAAVQW AQGVSVAAES
SLWAVANRIS HALGLTGPSI GVDSACSGAL NCVALAVDAI RSGQCDAAIA GGVNLILHPG
HHAGLAQAKM LAQGRDCRPF AEQGSGMVTG EGAGAVLLKS YAAAKADGDQ IYGVIAGVAS
NFKGQTSDGF AAPEAAAELA VMRRALAQAN IPVDNIDYLE VSATGVARGD AAECDAVSRF
IDETGKRTAT RIGSVKSQFG HLEAASGMAQ LARVLLQMKH RQWLPTYGSD LPASLQERAC
FIEQSKRAWP DENSIHYAGI NAFAAGGSYV HLIVRNAPET QNANMQSAEI NNPLATLFPL
SARNPDQLKQ VGFNLLQQVR AQSNMRLSQI AFTLQRGRKS LKYRALLVAD SVQALQAELE
RLADGFTYEP DIAALPSQLQ QIAQQWLAGN TVDWVGQYSG VVPGVVSLPG YPFARKSFWL
AANNLVDSAN IAPSQPQIEQ SESATGSSVQ PSLQTPAHAK AENPSISQMA ASQQQGATQT
MSVESHAQLV RTISSLIADL QNIPLEEIDA DARFEEFGFD SISYVEFAER LQNQFEFKVD
ATVFYQCTDI PQLADFVAEN RPAGESSAPQ HTSDGLPAQI ASQSVATVAQ AAPPQSVAQV
RSVTQVQSVD QVQSIAQAQP VQSNKESTEN RGAMAIIGMS GQFPGSRDLN QFWQNLIAGE
QAITTIPSDR FDASGIIIPE TNLTYNTGGF IDDIDMFDAE FFQISPREAR LMDPQHRLML
QTLFHTIADA GYHHTQLAGT DTGVFVGVGA NSYGQLLVAA GEDVDGHMAT GNVHSVLVNR
ISYLLDLTGP SEPINTACSS SLVAVHRAVQ AIRNGECSSA LVGGVNLMLD ETGHAAFAKS
GMLSASGSCH TFDASADGYA RGEGCAGIWI KPLAQAQADG DHIYACVAGT AVGHGGRATS
LTAPNVGAQK KVVQRALADA GLDAEALTYI ETHGTGTALG DPVEINALKA VFAQSNAPCA
LGAVKTNIGH LETAAGIAGL IKTVLCLENK MLPAIAGLDT VNPLIDLDDS CLYLNRQLTP
WVNHERARYA GVSSFGFGGV NSHVIVGEAP AQAQTAYREL PAGPFLATLS APTQEQLEAY
ASSLKLWLSR QAQVEIADLC YTLQMSRSQD VKRLAFVVSS TKDLYTQLDQ FCSDPTASKA
FVSPAVNVAG QALFDAEDTA AILESVIAQK NWGKLAKLWV NHVPLTLPLV GNMTGEGSGP
MRRLSLPPVP FKQMRYWPKA SAAAVVPAPA AAIEPKTQTN PAPVSTSAPV PSQSASPATA
APATVKPAAA PAKSAVKDKA TNTTTRQPAP TVLAETPKQK NPAEKASGTA QSTLSFSEQI
QADVRAIIVD ALDIEAGNLV DDKPFPEYGI DSIIGLRVMQ KVQQRYGENL AMSAIIEEPT
VLRLSQFIES NTSVKPELNT SSAAANSEDT TPAVRVRISQ FGSAQMQTAW LFIADVSGEL
SWALNWMETS QDVQILGLEW SLADSPPSVN SIFDAVITQL AAVECNELVL VTKGYMAEFS
VGLAQVIQKQ RGITTHLKFI SPQHGKFLDQ GNFLTDLATT CSTVWRGRST VAYESMSEPE
KIHEIQEMAL ELMPRAAFDG WFDALMLNAQ RLIPLLTGYM PPVWVNTYDS EIILSYEGEE
VNLAKILVPP ASVLRLNTTE CLSRLAVTQY EKTYNVLAPG QQHDFPLVFV NREGDKTPTF
WVHTLFGDVS FTLNLAHHLG KACPVLGIEQ FTVDGDLHLL PSIKQMASHY IESIQTENPD
GPYIIGGYSF GGVVAYEMCR QLAELGKPVE MLVMIDSFMP NTETFGSIDI TNVEVENFDV
MALLLVANNF ARRFKITDEL RLDHVDGLPL NQQFDVVSQF LQGGKTSLTY DEIYQLVENN
YNTILTNNDA LTGYQPESLP ESINVLLFHA TQGFIAADNI YGMPEVRVTV EDRSNGFEPY
VKGQLNIIDV EADHYSICHD RKLVELSKSI LAQVTVDDNT DHA
//
