ID C5BZF5_BEUC1 Unreviewed; 363 AA.
AC C5BZF5;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=3,4-dihydroxyphenylacetate 2,3-dioxygenase {ECO:0000313|EMBL:ACQ79127.1};
GN OrderedLocusNames=Bcav_0866 {ECO:0000313|EMBL:ACQ79127.1};
OS Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Beutenbergiaceae;
OC Beutenbergia.
OX NCBI_TaxID=471853 {ECO:0000313|EMBL:ACQ79127.1, ECO:0000313|Proteomes:UP000007962};
RN [1] {ECO:0000313|EMBL:ACQ79127.1, ECO:0000313|Proteomes:UP000007962}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-8 / DSM 12333 / NBRC 16432
RC {ECO:0000313|Proteomes:UP000007962};
RX PubMed=21304633; DOI=10.4056/sigs.1162;
RA Land M., Pukall R., Abt B., Goker M., Rohde M., Glavina Del Rio T.,
RA Tice H., Copeland A., Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D.,
RA Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA Pati A., Chen A., Palaniappan K., Hauser L., Chang Y.J., Jefferies C.C.,
RA Saunders E., Brettin T., Detter J.C., Han C., Chain P., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA Lapidus A.;
RT "Complete genome sequence of Beutenbergia cavernae type strain (HKI
RT 0122).";
RL Stand. Genomic Sci. 1:21-28(2009).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|RuleBase:RU000683};
CC -!- SIMILARITY: Belongs to the extradiol ring-cleavage dioxygenase family.
CC {ECO:0000256|ARBA:ARBA00008784, ECO:0000256|RuleBase:RU000683}.
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DR EMBL; CP001618; ACQ79127.1; -; Genomic_DNA.
DR AlphaFoldDB; C5BZF5; -.
DR STRING; 471853.Bcav_0866; -.
DR KEGG; bcv:Bcav_0866; -.
DR eggNOG; COG0346; Bacteria.
DR HOGENOM; CLU_052361_3_0_11; -.
DR OrthoDB; 317332at2; -.
DR Proteomes; UP000007962; Chromosome.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0008198; F:ferrous iron binding; IEA:InterPro.
DR GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR CDD; cd07256; HPCD_C_class_II; 1.
DR Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 2.
DR Gene3D; 4.10.1270.10; homoprotocatechuate 2,3-dioxygenase domains; 1.
DR InterPro; IPR011981; DHPA_dOase_Mn/Fe.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR InterPro; IPR044904; HPCD_C_sf.
DR InterPro; IPR037523; VOC.
DR InterPro; IPR000486; Xdiol_ring_cleave_dOase_1/2.
DR NCBIfam; TIGR02295; HpaD; 1.
DR PANTHER; PTHR21366:SF27; BLL2967 PROTEIN; 1.
DR PANTHER; PTHR21366; GLYOXALASE FAMILY PROTEIN; 1.
DR Pfam; PF00903; Glyoxalase; 2.
DR SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 1.
DR PROSITE; PS00082; EXTRADIOL_DIOXYGENAS; 1.
DR PROSITE; PS51819; VOC; 2.
PE 3: Inferred from homology;
KW Aromatic hydrocarbons catabolism {ECO:0000256|ARBA:ARBA00022797,
KW ECO:0000256|RuleBase:RU000683};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964, ECO:0000256|RuleBase:RU000683};
KW Iron {ECO:0000256|RuleBase:RU000683};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000683};
KW Reference proteome {ECO:0000313|Proteomes:UP000007962}.
FT DOMAIN 17..131
FT /note="VOC"
FT /evidence="ECO:0000259|PROSITE:PS51819"
FT DOMAIN 152..271
FT /note="VOC"
FT /evidence="ECO:0000259|PROSITE:PS51819"
FT REGION 339..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 363 AA; 40165 MW; BC4E1C81BE1FBDA5 CRC64;
MAEASAVVLP PPPDIVRCAS VELVVTDLAA ARRFWVDVLG LVVTSESDDV IHLRTFEEFI
HHNLVLREGP VAAAAAISYR VREPADLDRA EAFFAALGCR VERRPDGFAE GFGDTVRVED
PLGFPLELFH DAEHVERLAW AYDRQGTAPL VRLDHVNQVV PHVPSGRTYL EALGFRVTED
IQDADGVTYA AWLRRKPTVH DVALTGGDGP RLHHVAFATR ESHHVTALCD RLGALRRSDC
IERGPGRHGV SNAFYLYLRD PDGHRVEIYT QDYWTGDPDN PVVTWDVHDN QRRDWWGNPV
VPSWYTEASP VLDLSGSVRP LVTRHEAGEM DVTIGADGFS YTRPPGGSGD VDGAEGFKLG
TQL
//
