ID C5CBG1_MICLC Unreviewed; 336 AA.
AC C5CBG1;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=NADPH-dependent curcumin reductase {ECO:0000313|EMBL:SQG47509.1};
DE EC=1.3.1.- {ECO:0000313|EMBL:SQG47509.1};
DE SubName: Full=Predicted NADP-dependent oxidoreductase {ECO:0000313|EMBL:ACS31084.1};
GN Name=curA {ECO:0000313|EMBL:SQG47509.1};
GN OrderedLocusNames=Mlut_15930 {ECO:0000313|EMBL:ACS31084.1};
GN ORFNames=NCTC2665_00269 {ECO:0000313|EMBL:SQG47509.1};
OS Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 /
OS NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Micrococcus.
OX NCBI_TaxID=465515 {ECO:0000313|EMBL:ACS31084.1, ECO:0000313|Proteomes:UP000000738};
RN [1] {ECO:0000313|EMBL:ACS31084.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NCTC 2665 {ECO:0000313|EMBL:ACS31084.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Lowry S., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Young M., Greenblatt C.;
RT "Complete sequence of Micrococcus luteus NCTC 2665.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000000738}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 /
RC NCTC 2665 / VKM Ac-2230 {ECO:0000313|Proteomes:UP000000738};
RX PubMed=19948807; DOI=10.1128/JB.01254-09;
RA Young M., Artsatbanov V., Beller H.R., Chandra G., Chater K.F., Dover L.G.,
RA Goh E.B., Kahan T., Kaprelyants A.S., Kyrpides N., Lapidus A., Lowry S.R.,
RA Lykidis A., Mahillon J., Markowitz V., Mavromatis K., Mukamolova G.V.,
RA Oren A., Rokem J.S., Smith M.C., Young D.I., Greenblatt C.L.;
RT "Genome sequence of the Fleming strain of Micrococcus luteus, a simple
RT free-living actinobacterium.";
RL J. Bacteriol. 192:841-860(2010).
RN [3] {ECO:0000313|EMBL:SQG47509.1, ECO:0000313|Proteomes:UP000248985}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC2665 {ECO:0000313|EMBL:SQG47509.1,
RC ECO:0000313|Proteomes:UP000248985};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP001628; ACS31084.1; -; Genomic_DNA.
DR EMBL; LS483396; SQG47509.1; -; Genomic_DNA.
DR RefSeq; WP_010080500.1; NZ_LS483396.1.
DR AlphaFoldDB; C5CBG1; -.
DR STRING; 465515.Mlut_15930; -.
DR EnsemblBacteria; ACS31084; ACS31084; Mlut_15930.
DR KEGG; mlu:Mlut_15930; -.
DR PATRIC; fig|465515.4.peg.1531; -.
DR eggNOG; COG2130; Bacteria.
DR HOGENOM; CLU_026673_29_2_11; -.
DR Proteomes; UP000000738; Chromosome.
DR Proteomes; UP000248985; Chromosome 1.
DR GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05288; PGDH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR041694; ADH_N_2.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR045010; MDR_fam.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR PANTHER; PTHR43205:SF7; PROSTAGLANDIN REDUCTASE 1; 1.
DR Pfam; PF16884; ADH_N_2; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:SQG47509.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000738}.
FT DOMAIN 20..334
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 336 AA; 35618 MW; EB4E1C84A6D17E97 CRC64;
MSTPTRTREI HLASRPHGAP TPENFRLTEV ELPELAEGQV LVRNTVMSVD PYMRGRMNDV
ESYVPPFQLD APLDGGAVGT VIASRHADVP EGTSVLHGLG WREHAVLDGD TVQAVDTSQF
SDSTYLGVLG MTGLTAYTGL VHVAEMQEGD AVFISGAAGA VGSVAGQIAR LLGASRVVGS
AGTPEKVARV KELGFDAAFD YHDGSPTDLL AEAAPEGIDV YFDNVGGDHL EAAIAAMRVD
GRVAMCGAIA QYNSTEPPAA PRNLALAIGK CLTLRGFVLQ KYAAQVRPEF LERVGPWVAA
GKIQWDETVR EGLENAPQAF IDLLEGANTG KMLVRL
//
