ID   C5CF66_KOSOT            Unreviewed;       595 AA.
AC   C5CF66;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   SubName: Full=CoA-substrate-specific enzyme activase {ECO:0000313|EMBL:ACR79343.1};
GN   OrderedLocusNames=Kole_0626 {ECO:0000313|EMBL:ACR79343.1};
OS   Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1).
OC   Bacteria; Thermotogota; Thermotogae; Kosmotogales; Kosmotogaceae;
OC   Kosmotoga.
OX   NCBI_TaxID=521045 {ECO:0000313|EMBL:ACR79343.1, ECO:0000313|Proteomes:UP000002382};
RN   [1] {ECO:0000313|EMBL:ACR79343.1, ECO:0000313|Proteomes:UP000002382}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1733 / DSM 21960 / TBF 19.5.1
RC   {ECO:0000313|Proteomes:UP000002382};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA   Noll K.;
RT   "Complete sequence of Thermotogales bacterium TBF 19.5.1.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACR79343.1, ECO:0000313|Proteomes:UP000002382}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1733 / DSM 21960 / TBF 19.5.1
RC   {ECO:0000313|Proteomes:UP000002382};
RX   PubMed=21914881; DOI=10.1128/JB.05828-11;
RA   Swithers K.S., Dipippo J.L., Bruce D.C., Detter C., Tapia R., Han S.,
RA   Goodwin L.A., Han J., Woyke T., Pitluck S., Pennacchio L., Nolan M.,
RA   Mikhailova N., Land M.L., Nesbo C.L., Gogarten J.P., Noll K.M.;
RT   "Genome Sequence of Kosmotoga olearia Strain TBF 19.5.1, a Thermophilic
RT   Bacterium with a Wide Growth Temperature Range, Isolated from the Troll B
RT   Oil Platform in the North Sea.";
RL   J. Bacteriol. 193:5566-5567(2011).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR   EMBL; CP001634; ACR79343.1; -; Genomic_DNA.
DR   RefSeq; WP_012745125.1; NC_012785.1.
DR   AlphaFoldDB; C5CF66; -.
DR   STRING; 521045.Kole_0626; -.
DR   KEGG; kol:Kole_0626; -.
DR   eggNOG; COG1924; Bacteria.
DR   HOGENOM; CLU_029109_0_0_0; -.
DR   Proteomes; UP000002382; Chromosome.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.40; -; 4.
DR   InterPro; IPR002731; ATPase_BadF.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR008275; CoA_E_activase_dom.
DR   NCBIfam; TIGR00241; CoA_E_activ; 1.
DR   PANTHER; PTHR32329:SF7; ACTIVATOR OF 2-HYDROXYACYL-COA-HYDRATASE-RELATED; 1.
DR   PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR   Pfam; PF01869; BcrAD_BadFG; 2.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023014};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002382}.
FT   DOMAIN          74..218
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          291..544
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
SQ   SEQUENCE   595 AA;  65209 MW;  2CD1919716F9AD7A CRC64;
     MDLKSIGVCV GSSNISYYDG IKGENVSHHG NPMEILKELI PRFLIDGNVI VTGRKAKKMV
     KLSQIPEVEA TEIAYNTLRD KYGAVEGIVS AGGENFILYK LNEKGSIIGI YTGSKCASGT
     GEFFLQQLKR MDVSLDFANS IEIDECYELS SRCTVFCKSD CTHALNKCVP KELILNGLGK
     VMAEKIMELV HKSGVKKIML VGGTARNKVM VKHLLKRIDL VIPDEALFFE AFGAHVWGKR
     NSAFAFKAQG TIFVESPSSF SRHAPLKKFL NMVEFKKMNF EKAQNGNDCI LGVDVGSTTT
     KAVLVRLRDN AILTGSYLRT LGDPIRAVKN CYNELIKQLK GINLRIIGVG ITGSGRKVVG
     LYSQTNAVYN EITAHARAAA YFDSEVDTIF EIGGQDAKYT YLVNRVPTDY SMNKACSAGT
     GSFLEEATKE SLEVHYLDIG DLALESENPP NFSDQCAAFI SSDVKTAIHE GLSREDICAG
     LVYSICMNYL NRVKGNRPVG KKIIMQGGVC YNRAVPAAMA ALTGKRIVIP PHPGLMGAYG
     VALIVKENIK QGFLKPSNFD LRELANREVQ YKGTFICPGG KKSYTAPLKN WTGKK
//