ID C5CQ60_VARPS Unreviewed; 337 AA.
AC C5CQ60;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=Pyruvate dehydrogenase (Acetyl-transferring) {ECO:0000313|EMBL:ACS21632.1};
DE EC=1.2.4.1 {ECO:0000313|EMBL:ACS21632.1};
GN OrderedLocusNames=Vapar_5030 {ECO:0000313|EMBL:ACS21632.1};
OS Variovorax paradoxus (strain S110).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=543728 {ECO:0000313|EMBL:ACS21632.1};
RN [1] {ECO:0000313|EMBL:ACS21632.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S110 {ECO:0000313|EMBL:ACS21632.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Orwin P.,
RA Leadbetter J.R., Spain J.C., Han J.I.;
RT "Complete sequence of chromosome 1 of Variovorax paradoxus S110.";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP001635; ACS21632.1; -; Genomic_DNA.
DR AlphaFoldDB; C5CQ60; -.
DR STRING; 543728.Vapar_5030; -.
DR KEGG; vap:Vapar_5030; -.
DR eggNOG; COG1071; Bacteria.
DR HOGENOM; CLU_029393_5_0_4; -.
DR OMA; NHWAISE; -.
DR OrthoDB; 9766715at2; -.
DR GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ACS21632.1}; Pyruvate {ECO:0000313|EMBL:ACS21632.1}.
FT DOMAIN 41..321
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 337 AA; 34715 MW; 0052289A5B0FB692 CRC64;
MDPSNSGTAL YRAMVRIRAF ENAAEAASQG GVSAYGQQAA GAAKVRGPLH LSTGQEAVPA
GVCAHLRTSD YLTSTHRGHG HTLAKGADLA RMMCELFGKA TGFNGGKGGS MHIADFSVGM
LGANGVVAAG LPIAVGAAHA QKLLRKNNDI TVCFFGDGAI NRGPFLEALN WARVYGLPVL
FVCEDNRWSA TTASGPMTAG DGASARAASM DIAATQVDGN DVFAVHETAA RLVAEVRGGG
GPRLLHALTY RVKGHVSVDL AAYRDPAELA AALETDPIAR ARGQLLDMGV DAATLDAIEN
AARDEVDTAL AVADAAPWPE ASAAFTDVQT TGAGQWY
//