ID C5CZD8_VARPS Unreviewed; 611 AA.
AC C5CZD8;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
DE Flags: Precursor;
GN OrderedLocusNames=Vapar_5344 {ECO:0000313|EMBL:ACS21946.1};
OS Variovorax paradoxus (strain S110).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=543728 {ECO:0000313|EMBL:ACS21946.1};
RN [1] {ECO:0000313|EMBL:ACS21946.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S110 {ECO:0000313|EMBL:ACS21946.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Orwin P.,
RA Leadbetter J.R., Spain J.C., Han J.I.;
RT "Complete sequence of chromosome 2 of Variovorax paradoxus S110.";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP001636; ACS21946.1; -; Genomic_DNA.
DR AlphaFoldDB; C5CZD8; -.
DR STRING; 543728.Vapar_5344; -.
DR KEGG; vap:Vapar_5344; -.
DR eggNOG; COG4191; Bacteria.
DR HOGENOM; CLU_000445_94_2_4; -.
DR OrthoDB; 9772100at2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR017055; Sig_transdc_His_kinase_DctB.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PIRSF; PIRSF036431; STHK_DctB; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000313|EMBL:ACS21946.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000313|EMBL:ACS21946.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 309..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 384..597
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 611 AA; 65736 MW; 402F6B7B8A7E8501 CRC64;
MIPREPARRF DLPSRSPRRW RGLPRWCGAL ALVAAAAFAG HHFAMQNGLA RLREAADHRL
DMLATGLDAD LARFEYLPAL LEMTPIVPGL LGTPSDAPLR DAVNRYLDGV NAAAGAEMLY
VLDAAGTSLA ASDWNRPGTT VGQDLSFRPY VIDALGQGKG RFYGVGITSR KPGYYLSYAL
RRGQPTRGVV AVKVNLEETE RAWRKLPGDV ALIDQRGVVI LATREELKFR PLLPLDAVQR
AEVQRSRPYG EAGLQPLQWT LKQTLARDVK VIALDGVDQL ASTRSLRGAP WQLMALDDLA
PVRVGARNAA ITASLAMAVL LLMAVTLWQR RRAVRQKLAN QAALQAAHDT LESTVVARTA
QLRAAQGELV HAGKMAALGQ MSAGVVHELN QPLTAMRTLS ESAAILLDKN RLDDVRGNLQ
RIRGMVDRLA RLTSQLKTFA HKNELPLAAV LMARAVADAQ AIVAEATKKN GVAIEVDVQP
ASLSVMAEEA ALGSVLVNLM RNAIDAMQAS PRRRLRLEAR PQEGRVILRV SDTGPGIPPD
ILPRLFEPFV SSKPAGAGLG LGLAISAQLV RAMDGTLRAA NLPEGGACFV ADLPAAVYAI
PIPALTGVIN K
//
