ID C5D169_VARPS Unreviewed; 723 AA.
AC C5D169;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase with extracellular sensor {ECO:0000313|EMBL:ACS22670.1};
DE Flags: Precursor;
GN OrderedLocusNames=Vapar_6106 {ECO:0000313|EMBL:ACS22670.1};
OS Variovorax paradoxus (strain S110).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=543728 {ECO:0000313|EMBL:ACS22670.1};
RN [1] {ECO:0000313|EMBL:ACS22670.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S110 {ECO:0000313|EMBL:ACS22670.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Orwin P.,
RA Leadbetter J.R., Spain J.C., Han J.I.;
RT "Complete sequence of chromosome 2 of Variovorax paradoxus S110.";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP001636; ACS22670.1; -; Genomic_DNA.
DR AlphaFoldDB; C5D169; -.
DR STRING; 543728.Vapar_6106; -.
DR KEGG; vap:Vapar_6106; -.
DR eggNOG; COG5000; Bacteria.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_70_50_4; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 212..264
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 307..441
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 450..704
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 723 AA; 78872 MW; 146408E8EB5D1D74 CRC64;
MRSLRVEIAL GFGVVIVLML ALGASFYLSE QRSAAAIDKL LSSDNRMADL SLRSSLAMYK
ARDAENELLL SADRLGVAQA SERSLPAMQN HLLDMREYLA SLRILSTDPK FRDQVDRIET
QTRQYEDGFL AFIARHGKEG LPESADALRQ GYLATAVAIE SSVEALHTEA TKRALQTRSD
VERAARFSRW AVIALVALAI LLSAAAATVV SRRITGSIAR LVAFSGRVAA GDFSARTPQG
HADEFGILAS AMNQMAESIE NSNALLESSA DTLKHQATHD PLTGLPNRAL LEDRLRQAIS
YADRYGRLMT VVFINLDGFK RINDSLGRKG GDELLKVMAE RMARCLRSVD TVVRTGGDEF
VIILYDQPGD GTDIAPALRK LLETIAQPAR IGSQAVQLTG SMGVATYPAD GADADALLVN
ADAAMSHAKA SGRNNFEFYA AEMSGAIRDE LALREGLRHA VARSEFHLAY QPQLDMESGR
VTGVEALIRW QHPERGLVSP AQFIPLAEET GLIVPIGEWV LRTACFQNKA WQDAGLPPFI
VSVNVSARQF RERTLIAQVA LALRDSGLEP RLLELELTES LVMEDLDKAL QSMKALRAMG
VQLSIDDFGT GYSSLSALKR FPIARLKIDQ SFVRDIPGDE EDKAIAKTII ALGHELNLKV
IAEGVETEQQ LEFLRAHGCD EMQGYLFSRP VPPAELAALV RMRAGEAAAS GQPEARARRV
AGR
//
