ID C5D376_GEOSW Unreviewed; 1177 AA.
AC C5D376;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 96.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN OrderedLocusNames=GWCH70_0050 {ECO:0000313|EMBL:ACS22992.1};
OS Geobacillus sp. (strain WCH70).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX NCBI_TaxID=471223 {ECO:0000313|EMBL:ACS22992.1};
RN [1] {ECO:0000313|EMBL:ACS22992.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WCH70 {ECO:0000313|EMBL:ACS22992.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA Brumm P., Mead D.A., Richardson P.;
RT "Complete sequence of chromosome of Geopacillus sp. WCH70.";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; CP001638; ACS22992.1; -; Genomic_DNA.
DR AlphaFoldDB; C5D376; -.
DR STRING; 471223.GWCH70_0050; -.
DR KEGG; gwc:GWCH70_0050; -.
DR eggNOG; COG1197; Bacteria.
DR HOGENOM; CLU_005122_2_2_9; -.
DR OMA; WAPPCRE; -.
DR OrthoDB; 9804325at2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR CDD; cd18810; SF2_C_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 638..799
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 816..974
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1177 AA; 135436 MW; FDD4AC63DF432242 CRC64;
MLSLHRYFVE NQDVRSIIEG VKARLKEQLV VGLSGSARSV FISSLYRETE RPLLVIAHNL
FQAQKIYDDL VQLLGAEEVF LYPVNEVIAA EMAIASPELK AQRLEVMNYW LKHNKGVVIC
PVAGLRRLLP PVSLWRDHML TLEVHHHIDV EHYKQRFVQM GYKRVATVST PGEFSVRGGI
IDIYPLTAEF PYRIELFDTE IESIRTFTAD DQRSRDEVQQ VTIGPADEMI VYGEMLERGI
ERIEAGLAES LNKLKDEKAK QLLLEHVSSE LEQLKQGQEI EQQYKYTALF YNEPASLLDY
MPENGILLMD EMSRLQEMAE SLDKEEAEWY TSLLSEGKII HDVPISHSFS ELLQKHPKQR
IYLSIFLRHV PHTHPENIVN ISCKQMQNFH GQMSLLKSEL ERWKKANYAV VFLAPNAERM
KKLQSVFEDY EIDVAPLSDE AMLMHGKYQM LEGDLNTGFE LPMQKLAVIT EEELFKKRAK
RPIRRQKLSN AERIKSYSEL QVGDYVVHVN HGIGKYLGIE TLEINGVHKD YIHIQYQGSD
TLYVPVDQID QVQKYVGSEG KEPKIYKLGG SEWKKVKKKV ESSVQDIAED LIKLYAEREA
SKGYAFSPDT EMQREFEAAF PYQETEDQLR SIEEIKRDME SDKPMDRLLC GDVGYGKTEV
ALRAAFKAIM DGKQVAFLVP TTILAQQHYE TVRERFQGFP INVGLLNRFR TRKQQAETIK
GLKDGTIDMV IGTHRLLSKD VQFKDLGLLI IDEEQRFGVT HKEKIKQLKA NIDVLTLTAT
PIPRTLHMSM IGVRDLSIIE TPPENRFPVQ TYVMEYTPEL IREAIERELA RDGQVFFLYN
RIEDIDAKAE EISQLVPEAR VTYAHGRMTE NELESTMLAF LEGQYDVLVT TTIIETGVDI
PNVNTLIVYD ADRMGLSQLY QLRGRVGRSN RVAYAYFTYR KDKVLNEDAE KRLQAIKEFT
ELGSGFKIAM RDLSIRGAGN ILGAQQHGFI DSVGFDLYSQ MLKEAIEKRK GIKQEEAKPE
VTIDLEVDAY IPDTYISDGL QKIDMYKRFK AVETMEDVEA LRDEMLDRFG EYPDEVAYLF
QIAEIKVYAK QIGVESIKQQ KQQIEILFDE NASKDVEIQR LSKIGRQYGR LFGFGMEGSK
LKIVLYIKEL KPQEWLMILY ETLKELSGVK GEKSIIA
//