GenomeNet

Database: UniProt
Entry: C5D376_GEOSW
LinkDB: C5D376_GEOSW
Original site: C5D376_GEOSW 
ID   C5D376_GEOSW            Unreviewed;      1177 AA.
AC   C5D376;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 96.
DE   RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE            Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE            EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN   Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN   OrderedLocusNames=GWCH70_0050 {ECO:0000313|EMBL:ACS22992.1};
OS   Geobacillus sp. (strain WCH70).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=471223 {ECO:0000313|EMBL:ACS22992.1};
RN   [1] {ECO:0000313|EMBL:ACS22992.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WCH70 {ECO:0000313|EMBL:ACS22992.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Brumm P., Mead D.A., Richardson P.;
RT   "Complete sequence of chromosome of Geopacillus sp. WCH70.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC       polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC       release of RNAP and its truncated transcript from the DNA, and
CC       recruitment of nucleotide excision repair machinery to the damaged
CC       site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC       RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001638; ACS22992.1; -; Genomic_DNA.
DR   AlphaFoldDB; C5D376; -.
DR   STRING; 471223.GWCH70_0050; -.
DR   KEGG; gwc:GWCH70_0050; -.
DR   eggNOG; COG1197; Bacteria.
DR   HOGENOM; CLU_005122_2_2_9; -.
DR   OMA; WAPPCRE; -.
DR   OrthoDB; 9804325at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR   CDD; cd17991; DEXHc_TRCF; 1.
DR   CDD; cd18810; SF2_C_TRCF; 1.
DR   Gene3D; 2.40.10.170; -; 1.
DR   Gene3D; 3.40.50.11180; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR   Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR   HAMAP; MF_00969; TRCF; 1.
DR   InterPro; IPR003711; CarD-like/TRCF_RID.
DR   InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR004576; Mfd.
DR   InterPro; IPR048635; MFD_D3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047112; RecG/Mfd.
DR   InterPro; IPR037235; TRCF-like_C_D7.
DR   InterPro; IPR005118; TRCF_C.
DR   InterPro; IPR041471; UvrB_inter.
DR   NCBIfam; TIGR00580; mfd; 1.
DR   PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR   Pfam; PF02559; CarD_TRCF_RID; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF21132; MFD_D3; 1.
DR   Pfam; PF03461; TRCF; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM01058; CarD_TRCF; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00982; TRCF; 1.
DR   SUPFAM; SSF141259; CarD-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR   SUPFAM; SSF143517; TRCF domain-like; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00969};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00969};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00969}.
FT   DOMAIN          638..799
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          816..974
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   1177 AA;  135436 MW;  FDD4AC63DF432242 CRC64;
     MLSLHRYFVE NQDVRSIIEG VKARLKEQLV VGLSGSARSV FISSLYRETE RPLLVIAHNL
     FQAQKIYDDL VQLLGAEEVF LYPVNEVIAA EMAIASPELK AQRLEVMNYW LKHNKGVVIC
     PVAGLRRLLP PVSLWRDHML TLEVHHHIDV EHYKQRFVQM GYKRVATVST PGEFSVRGGI
     IDIYPLTAEF PYRIELFDTE IESIRTFTAD DQRSRDEVQQ VTIGPADEMI VYGEMLERGI
     ERIEAGLAES LNKLKDEKAK QLLLEHVSSE LEQLKQGQEI EQQYKYTALF YNEPASLLDY
     MPENGILLMD EMSRLQEMAE SLDKEEAEWY TSLLSEGKII HDVPISHSFS ELLQKHPKQR
     IYLSIFLRHV PHTHPENIVN ISCKQMQNFH GQMSLLKSEL ERWKKANYAV VFLAPNAERM
     KKLQSVFEDY EIDVAPLSDE AMLMHGKYQM LEGDLNTGFE LPMQKLAVIT EEELFKKRAK
     RPIRRQKLSN AERIKSYSEL QVGDYVVHVN HGIGKYLGIE TLEINGVHKD YIHIQYQGSD
     TLYVPVDQID QVQKYVGSEG KEPKIYKLGG SEWKKVKKKV ESSVQDIAED LIKLYAEREA
     SKGYAFSPDT EMQREFEAAF PYQETEDQLR SIEEIKRDME SDKPMDRLLC GDVGYGKTEV
     ALRAAFKAIM DGKQVAFLVP TTILAQQHYE TVRERFQGFP INVGLLNRFR TRKQQAETIK
     GLKDGTIDMV IGTHRLLSKD VQFKDLGLLI IDEEQRFGVT HKEKIKQLKA NIDVLTLTAT
     PIPRTLHMSM IGVRDLSIIE TPPENRFPVQ TYVMEYTPEL IREAIERELA RDGQVFFLYN
     RIEDIDAKAE EISQLVPEAR VTYAHGRMTE NELESTMLAF LEGQYDVLVT TTIIETGVDI
     PNVNTLIVYD ADRMGLSQLY QLRGRVGRSN RVAYAYFTYR KDKVLNEDAE KRLQAIKEFT
     ELGSGFKIAM RDLSIRGAGN ILGAQQHGFI DSVGFDLYSQ MLKEAIEKRK GIKQEEAKPE
     VTIDLEVDAY IPDTYISDGL QKIDMYKRFK AVETMEDVEA LRDEMLDRFG EYPDEVAYLF
     QIAEIKVYAK QIGVESIKQQ KQQIEILFDE NASKDVEIQR LSKIGRQYGR LFGFGMEGSK
     LKIVLYIKEL KPQEWLMILY ETLKELSGVK GEKSIIA
//
DBGET integrated database retrieval system