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Database: UniProt
Entry: C5DCM3_LACTC
LinkDB: C5DCM3_LACTC
Original site: C5DCM3_LACTC 
ID   C5DCM3_LACTC            Unreviewed;       866 AA.
AC   C5DCM3;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   05-JUL-2017, entry version 43.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   OrderedLocusNames=KLTH0B04268g {ECO:0000313|EMBL:CAR21534.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21534.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21534.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P.,
RA   Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F.,
RA   Anthouard V., Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R.,
RA   Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T.,
RA   Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G.,
RA   Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C.,
RA   Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E.,
RA   Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C.,
RA   Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C.,
RA   Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CU928166; CAR21534.1; -; Genomic_DNA.
DR   RefSeq; XP_002551972.1; XM_002551926.1.
DR   STRING; 381046.XP_002551972.1; -.
DR   EnsemblFungi; CAR21534; CAR21534; KLTH0B04268g.
DR   GeneID; 8290809; -.
DR   KEGG; lth:KLTH0B04268g; -.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; C5DCM3; -.
DR   KO; K02154; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IEA:EnsemblFungi.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002036};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    456    480       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    500    518       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    601       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    607    631       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    672    690       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    773    793       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    805    828       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      115    149       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   866 AA;  98665 MW;  B1DFE79F06EB06EF CRC64;
     MTREEAIFRS ADMTYVQLYI PLELSREVVC LLGNMGNVMF RDLNTDLTTF QRGYVNQIRK
     FDDLERLIDY MSNVASRYSE ATWKYVFHGD NDNATQHPSM NFLMSSMHTH SLDTVSDLTA
     EITEFESRVR QLDESLVNLR KRLNTLIEHR HAAFECGRYM EVNPGLRGRA ARSQQHRDLE
     QLTVEDFRLS DDEVSETLSD TFSFDEVSED NSVPSAGRDL SAELEEGFRH RTTIIGSINR
     SKVETLNKIL WRILRGNLFF HNIPIEEPLL EKGELVQKDC FVVFTHGDVL LKKVKRVVES
     LNGTIFPGNE GRSTIKNLNT QIADLQQICQ TTEQTLHTEL LIVSDQLPMW RAVARREKLI
     YAALNLFRQE SQGLVAEGWL PSTELLIVSN ALKNHSENIG SENSAVVSVI KTSKKPPTYH
     RTNKFTQSFQ AIVDAYGIAT YKEVNPGLAT IVTFPFMFAI MFGDTGHGAI VFLIALFLVL
     NEKKLAQAQN GEIFDMAFSG RYVILLMGFF SIYTGLLYND IFSLSMTFFK SGWKWNSGFK
     EGEAIEATNT GVYPFGLDYA WHGTENNLIF SNSYKMKLSI LMGFIHMTYS LFFSLVNYRY
     FRSRVDIIGN FIPGFIFMQS IFGYLSWAII YKWSKDWIKD GKVAPGLLNM LINMFLAPGV
     VDEPLFRGQS YLQVFLLLCA LICVPWLLLY KPLKLRAQNK AAISNGYQNI HDQNASESLL
     ESQEDAGGEI LVTDYDENHS NTFEFGDIMI HQVIHTIEFC LNCISHTASY LRLWALSLAH
     AQLSSVLWTM TIANAFSSKD SGSPLAVIKV VFLFGMWFVL TVCILVLMEG TSAMLHSLRL
     HWVEAMSKFF EGDGYPYEPF SFKALD
//
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