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Database: UniProt
Entry: C5DF49_LACTC
LinkDB: C5DF49_LACTC
Original site: C5DF49_LACTC 
ID   C5DF49_LACTC            Unreviewed;       820 AA.
AC   C5DF49;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   05-JUL-2017, entry version 42.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   OrderedLocusNames=KLTH0D12210g {ECO:0000313|EMBL:CAR22804.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR22804.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR22804.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P.,
RA   Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F.,
RA   Anthouard V., Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R.,
RA   Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T.,
RA   Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G.,
RA   Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C.,
RA   Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E.,
RA   Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C.,
RA   Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C.,
RA   Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CU928168; CAR22804.1; -; Genomic_DNA.
DR   RefSeq; XP_002553242.1; XM_002553196.1.
DR   STRING; 381046.XP_002553242.1; -.
DR   EnsemblFungi; CAR22804; CAR22804; KLTH0D12210g.
DR   GeneID; 8295482; -.
DR   KEGG; lth:KLTH0D12210g; -.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; C5DF49; -.
DR   KO; K02154; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000002036; Chromosome D.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:EnsemblFungi.
DR   GO; GO:0016049; P:cell growth; IEA:EnsemblFungi.
DR   GO; GO:0043623; P:cellular protein complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0006797; P:polyphosphate metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002036};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    412    436       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    457    474       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    534    556       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    568    589       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    628    646       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    725    748       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    754    777       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   820 AA;  93710 MW;  F1F43FE0CC57CD66 CRC64;
     MSEKYEAMFR SAEMSLVQLY VPQEIARDTV YSLGNRGLVQ FRDLNRKVRA FQRTFVPEVR
     RLDELQRQYR YFYSLLCKYD IKLYEDFEDE EDEEVLAASP VASAHKLAPR TSKIDDHIEN
     GTLIEKRMQQ LVEASEQLEL QKSDLEQFRH VLKAGDEFFA QSAGLTSQDS GEENFPRSVS
     FVTGTIPRAK AGTLEQILWR VLRGNLFFRT VPITEPLYDA KAQKKIYKDA FIVFSYGDII
     LQRVKKVAES LDASLYEISD DQSNRSKQLS EVNSRLADVY TVLDTTNTTL ETELFAVSKE
     LHAWNTEIAR EKAVYETLNL FDFDSNRKTL VGEGWVPQDE LGSLQVQLAN LTETLGVDVP
     SIVQVLETNR TPPTFHRTNK FTAAFQNICD CYGTATYREV NPGLPTIVTF PFMFAVMFGD
     MGHGMLMSMV AGLLVFNEKA LGKMKRDEIF DMAFSGRYIL LLMGLFSIYT GFLYNDMFSK
     SLTLFKSGWE WPSHWHLGEA IEAKSVGTYV FGLDWAWHGT ENALLFSNSY KMKLSVLLGF
     IHMTYSYMFS LVNYVYFQKW IDIIGNFIPG LLFMQGIFGY LTVCIIYKWT IDWVAIGKPA
     PGLLNTLINM FLSPGTVEEE LYPHQAKVQV FLLIMALICI PCLLLIKPLH FKFTQDKHQH
     IALPDNEAGL VHHETNTGAG AVEDDDDDEE GGHGEEFGDV MIHQVIHTIE FCLNTVSHTA
     SYLRLWALSL AHAQLSTVLW TMTIQIAFSM RGFVGVVMTV ILFGMWFVLT CVILVLMEGT
     SAMLHSLRLH WVESMSKFFE GEGYPYEPFK FMPVEFENEQ
//
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