ID C5DFF3_LACTC Unreviewed; 1267 AA.
AC C5DFF3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=KLTH0D14630p {ECO:0000313|EMBL:CAR22908.1};
GN OrderedLocusNames=KLTH0D14630g {ECO:0000313|EMBL:CAR22908.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR22908.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR22908.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
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DR EMBL; CU928168; CAR22908.1; -; Genomic_DNA.
DR RefSeq; XP_002553346.1; XM_002553300.1.
DR AlphaFoldDB; C5DFF3; -.
DR STRING; 559295.C5DFF3; -.
DR GeneID; 8295590; -.
DR KEGG; lth:KLTH0D14630g; -.
DR eggNOG; KOG0947; Eukaryota.
DR HOGENOM; CLU_002902_1_4_1; -.
DR InParanoid; C5DFF3; -.
DR OMA; CGSDITR; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000002036; Chromosome D.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 2.30.30.1160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR048727; Ski2_beta-barrel.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF21409; Ski2_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 328..486
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 592..794
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 529..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 215..245
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 529..546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1267 AA; 143743 MW; 0253156B8AC117D2 CRC64;
MAMEAKNLDL EELFQSLKEI TNEGSEKFEN VRTKRAVDDA SQEIDREDLI GKFLQPSNTL
PWGLLDLFQT VPEMNFMGDP EKSKDADYDY KEFLQIPELL KRTSYHFKRK GIDGKIDSYT
ESVNLSEIAN ANASNSLSIS RKINTENKSV RGSTGQLPFT PGGLTMSAFG QASDASAMAS
ATKLLHRDEQ GLFDIPQGLE RGIIPQEISM DGSNQIEELN ALNEIDNELE NLQEISENRR
KEDSKLEKDA SEAILGNAAQ DSDVEIDDLL PVGIDFGRTI RKAKNDLGRK EWAHVVDLNH
KIENFDELVP SPARTWPFEL DVFQKEAVYH LEQGDSVFVA AHTSAGKTVV AEYAIAMAKR
NMTKTIYTSP IKALSNQKFR DFKEDFEDVD VGLITGDVQI NPEANCLIMT TEILRSMLYR
GADLIRDVEF VIFDEVHYVN DQDRGVVWEE VIIMLPQHVK FILLSATVPN TYEFANWIGR
TKQKNIYVIS TPKRPVPLEI NIWAKDRLVP VINEKREFLE ANFKAHKELV SGKSGPPDRK
NEKPGASRGR GGSARGGGAG RGGAGRGGSR GAGAVGSNRS DFFKRSGPNK KTWTNLVNHL
KSKDLLPAVI FVFSKKRCED YADWLDGINF CTAKERSQIH MFVEKSVTRL KKEDRDLPQI
IKMKSLVERG IAVHHGGLLP IVKELIELLF AKGLIRVLFA TETFAMGLNL PTRTVVFSEI
QKHDGNSLRN LNPGEFTQMA GRAGRRGLDK TGTVIVMSYT SPLEQASFKE VALGVPTRLQ
SQFRLTYNMI LNLLRIEALR VEEMIKYSFS ENSKQTLLPE HENKIKSLQS QLDSIEFYEC
PHCEKDLDKA LDATIRYKEC TKDLMNELSS GSSVFRVLNV GRLILFRDLN DCAKLGFVFR
NLPKEGQVVV MTITNPSTLE NGQPNHLPYL STIPDFVKNN FKPFEKIEFF MENISMDSIE
IISAFTLDVP MTDIMKQEPE VIDKFKSEVS LIIRISRKLR ETKYEKKGSL KIHQAVLDRE
KIKTELASYE CSRCPNFDVH FLPKYKEFEI QRDIKSLYHL MSDQNLSLLP DYEQRLSVLK
DAGFIDQNHN VLLKGRVACE INSGYELVLT ELILDNFLGD FEPEEIVALL SVFVYEGRTR
EEEPLVTTPR LTKGKARIQE IYKAMLNVYE KHQVPLTKDE AEFLEKKRFA LMNVVYEWAR
GLSFKEIMEM SVESEGTIVR VITRLDEICR EVKTASIIIG NSNLHMKMSQ AQELIKRDIV
FAASLYL
//
