ID C5DH38_LACTC Unreviewed; 1177 AA.
AC C5DH38;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=KLTH0E01100g {ECO:0000313|EMBL:CAR23099.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR23099.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR23099.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CU928169; CAR23099.1; -; Genomic_DNA.
DR RefSeq; XP_002553536.1; XM_002553490.1.
DR AlphaFoldDB; C5DH38; -.
DR STRING; 559295.C5DH38; -.
DR GeneID; 8291674; -.
DR KEGG; lth:KLTH0E01100g; -.
DR eggNOG; KOG0519; Eukaryota.
DR HOGENOM; CLU_003731_0_0_1; -.
DR InParanoid; C5DH38; -.
DR OMA; WGDSNRI; -.
DR OrthoDB; 1222064at2759; -.
DR Proteomes; UP000002036; Chromosome E.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 2.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 487..519
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 552..943
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1038..1159
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 715..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..798
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..827
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..983
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1093
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1177 AA; 130007 MW; 86C7A8E940447EF0 CRC64;
MARLKKFDLG AYAKRKLKPP FLISIRTQLT ALVCLVALLS LIILAVITGV YFTSSFKSMR
AERLYVASQL KASQIDQNLY YLYYQCYYLS TRDVLQNALT QYLAGNTTTE NWADAVTTLD
KFLGSSNLFS LARVYDSSFQ DVLNASNNAS GNLVPESVLT QLFPLSTNVS LPSSLEVKGM
LTDPVLNDTG YLMSMSLPIF ANPSIILSTS KVYGYITVVI SAEGLKTVFN DTTALEDSSV
ILVSTVYDNR ELAGYHLVFP PYGMPSDIID KRYTIGNDSF LMDAFKQSKG GSIKSTHFLY
SKAVAIGYSP CSSDLVQWVA IITQPESKFL YPSTRLARII VGTCVAIAVV TCAVTFPLSH
WAVQPIVRLQ KATEIITAGR GLRSDNGSTL YSHKRSSTAE SFSSALHPAS IRRSGSVARS
SKHKYIPESA KGTLNKNDFE EIQPDGIENN EDAALQKVHS PTPGSLFSEQ RSARSERYIT
STNLIEARVP TYNRLFSDEL SELTETFNTM TDELDRHYAL LEDRVRARTR QLEAAKIEAE
GANEAKTVFI ANISHELRTP LNGILGMTAI AMAENDMQKV KSSLKLIFRS GELLLHIMTE
LLTFSKNVLK RTKLEERDFT VHEIALQVES IFGKLAKDQH VNLTISIIPN VLRTMVLWGD
SNRIVQIVMN LVSNALKFTP VDGRVNVKFT LLGEYDESKA SNGCFDRAAV VPIQESEKES
STLGPTEKGG IKDVTESASS SNATWPPSPS TSETSNGSKA ETTSGKLTES SEEDEKEEKL
DHDDKDEGDE ESEEEEYRGE AEVSGKDDTN NETQREDSNE NQNEDARSIE SENASSYDDA
IFHSRLRKGN SGENEDGRPL EHPRRLAIAM EVQDTGPGIE PALQESVFEP FVQGDQTLSR
QYGGTGLGLS ICRQLAAMMN GSMSLDSKVG VGSKFTFTVP LTQTKELCFE EDENPFEDEF
NPDSKKNRKV KFKVSKNNKR KKSHSSSSGQ NSSVGTPTVS ESEVSVGSVR VDRPFLQSTG
TALSTRSVTT TSVANKCKVL VAEDNNVNQE VIKRMLNLEG LDDVDLACDG QDAFDKVKAR
NEAGKFYDLI FMDVQMPRVD GLSATRMIRN ELSYTHPIVA LTAYADDRNI KECIDAGMNG
FLAKPIRRPK IKEILSEYCP TYFKADGEKK GKTEGQA
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