ID C5DS67_ZYGRC Unreviewed; 1029 AA.
AC C5DS67;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|RuleBase:RU365058};
GN OrderedLocusNames=ZYRO0B14278g {ECO:0000313|EMBL:CAR26628.1};
OS Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS / NRRL Y-229) (Candida mogii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX NCBI_TaxID=559307 {ECO:0000313|EMBL:CAR26628.1, ECO:0000313|Proteomes:UP000008536};
RN [1] {ECO:0000313|Proteomes:UP000008536}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC Y-229 {ECO:0000313|Proteomes:UP000008536};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC ECO:0000256|RuleBase:RU365058}.
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DR EMBL; CU928174; CAR26628.1; -; Genomic_DNA.
DR RefSeq; XP_002495561.1; XM_002495516.1.
DR AlphaFoldDB; C5DS67; -.
DR STRING; 559307.C5DS67; -.
DR GeneID; 8202727; -.
DR KEGG; zro:ZYRO0B14278g; -.
DR HOGENOM; CLU_012774_1_1_1; -.
DR InParanoid; C5DS67; -.
DR Proteomes; UP000008536; Chromosome B.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032993; C:protein-DNA complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd04720; BAH_Orc1p_Yeast; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR048867; ORC1_wHTH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF21312; ORC1_wHTH; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00439; BAH; 1.
DR SUPFAM; SSF82061; BAH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51038; BAH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058};
KW Reference proteome {ECO:0000313|Proteomes:UP000008536}.
FT DOMAIN 48..186
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 201..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..288
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..448
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1029 AA; 117838 MW; 93EC664B18F76971 CRC64;
MAETLKDIQG WEVITTDEKG NIINDNRRRS RKRGGSENTF LIRLKDGLKF GRGDSVIMHD
EATKTYSVYL IHEIRLNTLN NLVEIWAFSY LRWFELKPLL YYAHFDPGYA AENRPIEEYR
NRFIEDVNKS EIYLTAELSE IWLKDFVEVA RIMPEVDWKR SSQLEDKDFF VRFICEPTAE
SYVPIDIIKE QRLLQNTEPK SYEEHLKRMS VPPTLGRSKS GSTRRTNQVT SPSVNKIEDE
PETEDEEEDE TQEEEEETQE GEEEEYNEEG EEGEEEEEEE EEEEEEEVGK KNEGSSSEEK
EGFTGESRDS SRKDTTASKS QDFSTSQSPE AYSDAQETPS IASKTNPSGP QQAPAKENLL
GKLKAQKEDE GQNRASSAGK EDDVTVDESE ANKSETENNK DDKHEDSNAE EYVDEEEEDE
YAEQEEEEEE EEEEEEEEEE DEDEDEDYDQ KSSSKRGKSQ SPAKKSRKLA PLSTPVTPSK
PPNHNNNNTV SSPAIRKFTK RNVVRAKKKY TPFSKRFKSV DEIPDLTQLA ELNQSSNKLD
VAALENKLRT PKKHEIVETI FSRIKKQLYS SHEKEEIVKS TNFQDYLPAR ENEFASIYLS
LYSAIESGSA TTVYVAGTPG VGKTLTVREV VKELQRSADQ NELPLFQYVE INGLKMVKPT
DSYEVLWNKI MGERLTWGAA MESLEFYFNK VPQNKKRPVV VLLDELDALL TKTQDIMYNF
FNWTTYENAK LIVIAVANTM DLPERQLGNK VSSRIGLTRI MFTGYTHEEL RKIIDFRLKG
FNNSYFYVDT QSGSAHMLTP EEDTNTSELP PHTKKVQLRM SDDAIEIASR KVASVSGDAR
RALKVCKRAA EIAEQHYMSR HGYGYDGQAV LTPNEGEDAN DGDGLQTVHI THVLKALNET
VSSQGTQFIS NLSFTAKIFL YALLNLIKKT ELQEQQLGDI IDEIRLLIDV NGNNKFILEI
SRVLFQQGSE STPEQLKIIS WDFLLNQLVE AGIIFRQSMK NERLTCIKLN ISQEEVRKGL
EQDENLKSL
//
