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Database: UniProt
Entry: C5E3Z6_ZYGRC
LinkDB: C5E3Z6_ZYGRC
Original site: C5E3Z6_ZYGRC 
ID   C5E3Z6_ZYGRC            Unreviewed;       877 AA.
AC   C5E3Z6;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   05-JUL-2017, entry version 43.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   OrderedLocusNames=ZYRO0E01496g {ECO:0000313|EMBL:CAR30757.1};
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 /
OS   NCYC 568 / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
OC   Zygosaccharomyces.
OX   NCBI_TaxID=559307 {ECO:0000313|Proteomes:UP000008536};
RN   [1] {ECO:0000313|EMBL:CAR30757.1, ECO:0000313|Proteomes:UP000008536}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229
RC   {ECO:0000313|Proteomes:UP000008536};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P.,
RA   Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F.,
RA   Anthouard V., Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R.,
RA   Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T.,
RA   Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G.,
RA   Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C.,
RA   Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E.,
RA   Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C.,
RA   Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C.,
RA   Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CU928181; CAR30757.1; -; Genomic_DNA.
DR   RefSeq; XP_002499012.1; XM_002498967.1.
DR   STRING; 4956.XP_002499012.1; -.
DR   EnsemblFungi; CAR30757; CAR30757; ZYRO0E01496g.
DR   GeneID; 8204544; -.
DR   KEGG; zro:ZYRO0E01496g; -.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; C5E3Z6; -.
DR   KO; K02154; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000008536; Chromosome E.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IEA:EnsemblFungi.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008536};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008536};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    464    489       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    501    524       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    586    606       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    618    638       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    679    698       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    816    838       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      123    150       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   877 AA;  100787 MW;  16238C9FB0559B65 CRC64;
     MVREEAIFRS ADMTYVQLYI PLEISREIAC LLGNLGTLMF RDLNKDLTAF QRGYVGQIRK
     LDEVERLVLY MQEVSDKHAE ATWKYILHTD EQGNDIQRPS VTQLVSEMQT HSHDIINAAM
     GEIHEFEGRV KRLDDSLTNL KEKLNGLLEQ RYVIFEVTRF LQSHPGLFGR MGREERELRD
     VDEFRLNLDE LSETLSDTFS FEDGTEPTDE QQQQQEALND QMEFEADQNL LEIGFHDRFM
     IAGSIRRDKV EVLNRILWRL LRGNLIFQNF AIDEPLLENG EKVEKDCFFV FTHGEYLLQK
     VQRVVDSLNG RVVSLAHCTH REIQKLNDRI SEIQQIAYAT ESTLHAELLV VSDQLPVWNA
     MVKREKYIYA TLNLFKQETH GLVAEGWLPT LELTTISDAM KDYSETVGSE YSTVVSVIHT
     NRAPPTYHRT NKFTQAFQSI CDAYGTATYK EVNPGLATIV TFPFMFAIMF GDLGHGFILM
     LIGVFLLMME KKFETMQRGE IFDIVFTGRY VITLMGAFSV YTGLLYNDIF SKSMTIFKSG
     WKWPSNFKKG ESIVAEQTGT YPFGLDHAWH GTDNGLIYTN SYKMKLSVIM GFLHMTYSFM
     FSLVNYRYKK SRVDIIGNFL PGLIFMQSIF GYLTWAILYK WSKDWIKDNK PAPSLLNMLI
     NMFLSPGHID DQLYSGQNVL QILLLLAALA CIPWLLLYKP LTLKKQHSGV SLNGYESVNR
     SEGVDELTAD LQATEGDGMI VTDYHGHEEN EEFNFGEVMI HQVIHTIEFC LNCISHTASY
     LRLWALSLAH AQLSSVLWDM TIKNAFSPKN SGSPLAVTRV VLLFAMWFVL TVCILVLMEG
     TSAMLHSLRL HWVEAMSKFF EGDGYPYEPF TFKNLVE
//
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