ID C5FCR9_ARTOC Unreviewed; 631 AA.
AC C5FCR9;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Catabolite repression protein creC {ECO:0000313|EMBL:EEQ27603.1};
GN ORFNames=MCYG_00491 {ECO:0000313|EMBL:EEQ27603.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ27603.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Component of the regulatory network controlling carbon source
CC utilization through ubiquitination and deubiquitination involving creA,
CC creB, creC, creD and acrB. Required to prevent the proteolysis of the
CC CreB deubiquitinating enzyme in the absence of carbon catabolite
CC repression. CreB deubiquitinating enzyme stabilized in a complex with
CC the CreC leads to the expression of genes such as those in the proline
CC and quinate pathways. {ECO:0000256|ARBA:ARBA00037241}.
CC -!- SUBUNIT: Interacts with creB. {ECO:0000256|ARBA:ARBA00038682}.
CC -!- SIMILARITY: Belongs to the WD repeat creC family.
CC {ECO:0000256|ARBA:ARBA00038107}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS995701; EEQ27603.1; -; Genomic_DNA.
DR RefSeq; XP_002850387.1; XM_002850341.1.
DR AlphaFoldDB; C5FCR9; -.
DR STRING; 554155.C5FCR9; -.
DR GeneID; 9225609; -.
DR VEuPathDB; FungiDB:MCYG_00491; -.
DR eggNOG; KOG2394; Eukaryota.
DR HOGENOM; CLU_016971_1_1_1; -.
DR OMA; LHRPKAA; -.
DR OrthoDB; 1513505at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0045013; P:carbon catabolite repression of transcription; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR14107:SF16; AT02583P; 1.
DR PANTHER; PTHR14107; WD REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002035};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 368..418
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 418..459
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 76..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..95
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 631 AA; 69501 MW; AE43F51B43B4421F CRC64;
MSYSKAVTVE LTAHSFLPPP TPRYVNPVAY AAGTSNGLPV PITEVINVIK HPEGGCPLQV
GEGTYELRDD VHLATPPPHP SEPPVINPNP LATGPTPPTV GVKLSLVTLK QHRSGAQLYK
TNTRTSVTSD LRSVNESDSG GRSSTEQRVN GSAQAPPFGE GSLALISNGG KDTSGSKRRK
PKNNIQKSGS SFISRVILQD AMLKKVSERT HDNPFVFANL NRSFQWLDYS SSTKQDFLTK
ILFTKAHILS HDVNQITKSM SHLDLAMGSS AGDILWYEPF SQKYSRINKN GAIRNSPVNH
IKWIPGSENL FLAAHSDGCL VVYDKEKDDT LFTPEDSDNN PSLLSEGSGS NAHSSLFRIL
KSVNSKNQRT NPVAVWKLSN QKINSFAFSP DNRHLAVVLE DGTLRILDYL KEKLLDLYTS
YYGGLICVCW SPDGKYILTG GQDDLVSIWS FPERKIVARC QGHNSWVSCV EFDPWRCDDR
TYRFGSVGDD CRLLLWDFSV AMLHRPKAVT TRPRNSPQSP TRPHADSLTT RNIRSDSIRL
EKPADQTPII HPVEPRARTA QLPPIMSKEI GDDPICWLGF LEDSIMTSSL EGHIRTWDRP
SETASEPNAS TAGSSVAVGS LPRSIDGVHD L
//
