ID C5FE59_ARTOC Unreviewed; 332 AA.
AC C5FE59;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Dihydrodipicolinate synthetase family protein {ECO:0000313|EMBL:EEQ28093.1};
GN ORFNames=MCYG_00981 {ECO:0000313|EMBL:EEQ28093.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ28093.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
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DR EMBL; DS995701; EEQ28093.1; -; Genomic_DNA.
DR RefSeq; XP_002850877.1; XM_002850831.1.
DR AlphaFoldDB; C5FE59; -.
DR STRING; 554155.C5FE59; -.
DR GeneID; 9223614; -.
DR VEuPathDB; FungiDB:MCYG_00981; -.
DR eggNOG; ENOG502QWNS; Eukaryota.
DR HOGENOM; CLU_049343_0_2_1; -.
DR OMA; QAIKLSM; -.
DR OrthoDB; 1780992at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR PANTHER; PTHR12128:SF24; DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920); 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000002035}.
FT ACT_SITE 149
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 178
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 237
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 332 AA; 35698 MW; 7E523CF70759D237 CRC64;
MAERMKTPLQ PGVYVPTMTF FDTETEDLDI PTIRKHAVRL AKAGVSGLIT MGSNGEAVHL
SRAERALVTH HTRSALDEAG FKHIPVISGA TDQGVRGTIE ICREAADAGA EYILLISPSY
YRAAMGDQDT LFEYFTKVAD GSPLPIILYN FPGVVAGIDM DSDFIIRVSQ HPNIIGTKFT
CGSTGKLCRV AAAMNAITPA SPLTTSPERV ASAPYFAFGG YADFALQTLV SGGSGIVAGG
ANVLPRLCVE VFNLWSKGKL AEAMEMQKIL SDGDWIMSKY MIPGTKSAIH ACYGYGGYPR
APVPRLTEAQ EKEVAEKIKP AMIIEMKLKD AV
//
