ID C5FEL6_ARTOC Unreviewed; 412 AA.
AC C5FEL6;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Mitochondrial folate transporter/carrier {ECO:0000313|EMBL:EEQ28340.1};
GN ORFNames=MCYG_01228 {ECO:0000313|EMBL:EEQ28340.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ28340.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; DS995701; EEQ28340.1; -; Genomic_DNA.
DR RefSeq; XP_002851124.1; XM_002851078.1.
DR AlphaFoldDB; C5FEL6; -.
DR GeneID; 9228665; -.
DR VEuPathDB; FungiDB:MCYG_01228; -.
DR eggNOG; KOG0764; Eukaryota.
DR HOGENOM; CLU_015166_6_1_1; -.
DR OMA; AFYNGMG; -.
DR OrthoDB; 4772at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015218; F:pyrimidine nucleotide transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR049562; SLC25A33/36-like.
DR PANTHER; PTHR45829:SF1; CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED; 1.
DR PANTHER; PTHR45829; MITOCHONDRIAL CARRIER PROTEIN RIM2; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000002035};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 127..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 59..156
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 163..257
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 272..391
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 412 AA; 45680 MW; 245AB2D84149A526 CRC64;
MSLDRTKPAE TFNTQSSQQH QVSGPDSQAS TVPQLHPGAQ PPPNSTLLAR LQVYSTRIPQ
SYVTPFCGAG AGVASGIITC PLDVIKTKLQ AQGGFLRRNG KLVHTEALYK GMIGTGRTIW
RDEGLRGLYK GLGPMLLGYL PTWAVYLTIY DRARDYFYGR TENWWLARTY ASLTAGACST
IATNPIWVIK TRLMSQSIRP SNDGFQAPWY YKNTLDAARK MYASEGIRAF YSGLTPALLG
LSHVAIQFPL YEYFKLAFTG FMMGEHPDAG NPHWVGIGAA TFLSKICAST ATYPHEVLRT
RLQTQQRISP APSPEGISFR VSDDPYGGNV GAASSDGMRN RPRYRGVIRT FQTILKEEGW
RAFYAGIGTN LFRAVPSAMT TMLTYEYLRN IIHWGQHEGE IILASSVENQ HL
//
