ID C5FJU0_ARTOC Unreviewed; 427 AA.
AC C5FJU0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Transcription factor iws1 {ECO:0000313|EMBL:EEQ30951.1};
GN ORFNames=MCYG_03770 {ECO:0000313|EMBL:EEQ30951.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ30951.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC transcription regulation. May function in both SPT15/TBP post-
CC recruitment and recruitment steps of transcription.
CC {ECO:0000256|ARBA:ARBA00037349}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family.
CC {ECO:0000256|ARBA:ARBA00037992}.
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DR EMBL; DS995703; EEQ30951.1; -; Genomic_DNA.
DR RefSeq; XP_002848264.1; XM_002848218.1.
DR AlphaFoldDB; C5FJU0; -.
DR STRING; 554155.C5FJU0; -.
DR GeneID; 9229588; -.
DR VEuPathDB; FungiDB:MCYG_03770; -.
DR eggNOG; KOG1793; Eukaryota.
DR HOGENOM; CLU_045275_1_0_1; -.
DR OMA; RNNVQHA; -.
DR OrthoDB; 12240at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR Pfam; PF08711; Med26; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000002035}.
FT DOMAIN 252..329
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 427 AA; 48537 MW; 496855F60A89316F CRC64;
MSESPEPRLD SPALDKDENE DDVALDKDRD IAADISDDES VLSDVDEAQF EDFDPANVAI
DDRPALAIDE ENLKLVGRHK RRRTEEDGDG QTKKKKKEGR RDKKSHRKKQ GSEEFSGGEE
MDGKRRRKRR EGGGERAPRQ SKKQAEEEID EESLDPATRR RRALDRMMDE ALKKPSKRRF
KKADGIDLAD YADAEIEDVR KRMTDAARLD SIARKENRPA MHKLKMLPEV VSLLNRNQYV
NSLIDPEINL LEAVKFFLEP LDDGSLPAYN IQRDLLAALL RLPINKEALI ASGIGKVIVF
YTKSKRPEAG IKRQAERLLA EWTRPILQRS DDYSKRVYEE VDFDPSQLAD RTVSAEASAA
EARARELLPP RLANRARVES SHTTYTVVPR STGFSESKFA RPLGASGEDR FRRMKARQIA
ATKGSKR
//
