ID C5FN51_ARTOC Unreviewed; 797 AA.
AC C5FN51;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Lysophospholipase {ECO:0000256|ARBA:ARBA00013274, ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|ARBA:ARBA00013274, ECO:0000256|RuleBase:RU362103};
GN ORFNames=MCYG_04106 {ECO:0000313|EMBL:EEQ31287.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ31287.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000960,
CC ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
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DR EMBL; DS995704; EEQ31287.1; -; Genomic_DNA.
DR RefSeq; XP_002846369.1; XM_002846323.1.
DR AlphaFoldDB; C5FN51; -.
DR STRING; 554155.C5FN51; -.
DR GeneID; 9224438; -.
DR VEuPathDB; FungiDB:MCYG_04106; -.
DR eggNOG; KOG1325; Eukaryota.
DR HOGENOM; CLU_013227_1_0_1; -.
DR OMA; WALGRRF; -.
DR OrthoDB; 1997175at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR CDD; cd00147; cPLA2_like; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF40; LYSOPHOSPHOLIPASE; 1.
DR Pfam; PF01735; PLA2_B; 1.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW ProRule:PRU00555};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Reference proteome {ECO:0000313|Proteomes:UP000002035}.
FT DOMAIN 174..797
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
FT REGION 616..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 797 AA; 87137 MW; 587D509C27940322 CRC64;
MAGGQKAGDV NSQAVMAASE FLQARWRQAL KGALFVTGSA SLALLGKQSV RCDAGRSAAA
WNAKKTPQTA EESALDKLIK NSINNAGEKE EKKADEDAMS AWETMTDRLG TAEGYFSSSD
WSADWSAVFK DYISPGWTFF SPEILRNLQR ELSMAPGSVA DDVWKEACDP SFNPSIVEEA
NVRIGDTLCP EEESFLADRR KVVARNLASY LGLPEDQVHP DDVPVIAMCA SGGGLRALIA
GTGSYMAAKE AGLWDCLTYT AGVSGSCWLQ TLFNSSIGGQ DFGKMINHLK ARLHTHIAFP
PEALDILTTS PTNKYLLRGV IEKLKGDPKA DFGLVDVYGI LLAARLMVPQ DTAALTDSDL
QLSSQRAVVK GGANPMPIYT AVRHEIPKPS QMDASEDELE EISRRESWFQ WFEFTPYELF
CEEFAAGIPT WAVGRNFMNG KGVAAPHGYA VPELRVPALM GVWGSAFCAT LAHYYKEIRP
AFMGLAGFSS IDALIEGKSE DLTRVHPIDP ATVPNFVLGL EGKLPDSCPA SVFQDSHLRL
MDAGMSNNLP IYPLLRPGRN VDLIVAFDVS ADSKEANWLS VVDGYAHQRG IKGWPIGAGW
PKSNATPQET ADIIAEESQT TKEEADRKVA SAQEASKART RDSSGNDPDL TFCNIWLGTT
EESISSAESP PSKRLFHAST TNEEESEYHL TQPHAGIAVA YFPLLPNPAC LALPNPDKDE
KDGERKILNP LEEDYLSTWN FIYTAEQIDS AVHLAKSNFA EGEDQLKRVV RGIYERKKRE
RLQREMDGAR VSASYLA
//
