ID C5FT32_ARTOC Unreviewed; 694 AA.
AC C5FT32;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Calcium-binding mitochondrial carrier protein Aralar1 {ECO:0000313|EMBL:EEQ33035.1};
GN ORFNames=MCYG_05854 {ECO:0000313|EMBL:EEQ33035.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ33035.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBUNIT: Homodimer (via N-terminus). {ECO:0000256|ARBA:ARBA00038674}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
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DR EMBL; DS995705; EEQ33035.1; -; Genomic_DNA.
DR RefSeq; XP_002845985.1; XM_002845939.1.
DR AlphaFoldDB; C5FT32; -.
DR STRING; 554155.C5FT32; -.
DR GeneID; 9225960; -.
DR VEuPathDB; FungiDB:MCYG_05854; -.
DR eggNOG; KOG0751; Eukaryota.
DR HOGENOM; CLU_014931_2_0_1; -.
DR OMA; GPDAIPF; -.
DR OrthoDB; 1220009at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0043490; P:malate-aspartate shuttle; IEA:UniProt.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45678:SF9; CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1; 1.
DR PANTHER; PTHR45678; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000002035};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 166..201
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REPEAT 342..432
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 442..531
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 541..629
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 694 AA; 77082 MW; A70E80C5461A8001 CRC64;
MAQNIKEQLV GKSTETPLSA HVKAHFMQHA RVDGESGELY MTKEDFINAI APKNEDYHKI
KREQYGILFN VADRRRTGKI SLQDWSTFED LLAKPDAEYE ITFRLFDTEG TGIVKHETLQ
KLFTSAKGDS NIPFDWNSGW AALYTGSKKT RHDMTYPQFA QMLRGLQGER IRQAFHLFDK
DGDGYIEPED FQRIILETSQ HKLSDHLLEN LPTLCNISSG SKISYANVRA FQNIIREMDI
IDYIIRSAVR KSDDGKITRS DFLNEAARIT RFSLFTPMEA DILFHFAGLD APSGRLELGD
FAKVIDASWH SASVLGREAL AGASKASEKV TRKTSPLLHN ILESVHHFAL GSIAGAFGAF
MVYPIDLVKT RMQNQRSARV GEKMYMNSLD CAKKVVRNEG VLGLYSGVIP QLIGVAPEKA
IKLTVNDLVR GFFADKDKGG KIWWPHEVIA GGSAGACQVV FTNPLEIVKI RLQIQGEIAK
NVNETAPRRS AMWIVKNLGL MGLYKGASAC LLRDVPFSAI YFPTYSHLKT DFFGESSTKK
LGVIQLLTAG AIAGMPAAYL TTPCDVIKTR LQVEARKGET KYTSLRHCAT TILKEEGFKA
FFKGGPARIL RSSPQFGFTL AAYEVLQKWM PMPGTEHEEV TPTGYVEPGA SLQSASGPMP
YLRSRNALKL ILDLEPNFGR LQAPAGVSLP VLGK
//
