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Database: UniProt
Entry: C5FVB2_ARTOC
LinkDB: C5FVB2_ARTOC
Original site: C5FVB2_ARTOC 
ID   C5FVB2_ARTOC            Unreviewed;       580 AA.
AC   C5FVB2;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE            EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE   AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE   AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
GN   ORFNames=MCYG_06665 {ECO:0000313|EMBL:EEQ33846.1};
OS   Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ33846.1, ECO:0000313|Proteomes:UP000002035};
RN   [1] {ECO:0000313|Proteomes:UP000002035}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC         methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC         Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC         ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00029358};
CC   -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC       3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC       {ECO:0000256|ARBA:ARBA00025711}.
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DR   EMBL; DS995706; EEQ33846.1; -; Genomic_DNA.
DR   RefSeq; XP_002844701.1; XM_002844655.1.
DR   AlphaFoldDB; C5FVB2; -.
DR   STRING; 554155.C5FVB2; -.
DR   GeneID; 9227099; -.
DR   VEuPathDB; FungiDB:MCYG_06665; -.
DR   eggNOG; KOG0540; Eukaryota.
DR   HOGENOM; CLU_018822_0_1_1; -.
DR   OMA; AYLPIMS; -.
DR   OrthoDB; 5474505at2759; -.
DR   UniPathway; UPA00363; UER00861.
DR   Proteomes; UP000002035; Unassembled WGS sequence.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR034733; AcCoA_carboxyl_beta.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR011763; COA_CT_C.
DR   InterPro; IPR011762; COA_CT_N.
DR   InterPro; IPR045190; MCCB/AccD1-like.
DR   PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR   PANTHER; PTHR22855:SF13; METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL; 1.
DR   Pfam; PF01039; Carboxyl_trans; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 2.
DR   PROSITE; PS50989; COA_CT_CTER; 1.
DR   PROSITE; PS50980; COA_CT_NTER; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002035}.
FT   DOMAIN          74..331
FT                   /note="CoA carboxyltransferase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50980"
FT   DOMAIN          337..562
FT                   /note="CoA carboxyltransferase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50989"
SQ   SEQUENCE   580 AA;  61590 MW;  33069C129373197E CRC64;
     MALRAPSAGL LHSMRCALNQ QLPRRAALTL RAGSSYHVRG VASFTHAHQA SAISVLPTTV
     DTSSADFQEN AKQMEEVLKK MNDLHAKIAQ GGSQKARDKH IARGKMLPRD RVTALIDPGT
     SFLELSPLAG HEVYPGDDVP SGGIITGIGM VEGVNCMIVA NDSTVKGGTY YPITVKKHLR
     AQAIAQENKL PCIYLVDSGG ANLPHQADVF PDKEHFGRIF FNQARMSSLG IPQISVVMGP
     CTAGGAYVPA MCDESIIVEN QGTIFLAGPP LVKAATGEIV SAEDLGGGKL HSTISGVTDY
     LAVDDAHALT LARRSISNLN WPKTTSPLTP TSASTEPIKE PLYPTSELAG IIGTNLRRQV
     DAHEIIARIV DGSEFSEFKR DYGTTLVTGF ARIYGTQVGI VANNGILFSE SSLKGAHFIE
     LCTQRNIPLL FLQNISGFMV GADAEKGGIA KNGAKLVTAV ACADVPKFTV VYGASAGAGN
     YGMCGRAYSP RFLFMWPNAK IGVMGSEQLT NVMAAVGKSV DPSLRDRIDA ESEAVFSSAR
     LWDDGVIPPA DTRKVLGLCL AASVGGRSED AKTKFGVFRM
//
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