ID C5H0I1_BOACO Unreviewed; 220 AA.
AC C5H0I1;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:ACR53388.1};
OS Boa constrictor (Boa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Henophidia; Boidae; Boinae; Boa.
OX NCBI_TaxID=8574 {ECO:0000313|EMBL:ACR53388.1};
RN [1] {ECO:0000313|EMBL:ACR53388.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18570036; DOI=10.1080/10635150802166053;
RA Wiens J.J., Kuczynski C.A., Smith S.A., Mulcahy D.G., Sites J.W.Jr.,
RA Townsend T.M., Reeder T.W.;
RT "Branch lengths, support, and congruence: testing the phylogenomic approach
RT with 20 nuclear loci in snakes.";
RL Syst. Biol. 57:420-431(2008).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; EU402629; ACR53388.1; -; Genomic_DNA.
DR AlphaFoldDB; C5H0I1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 119..220
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACR53388.1"
FT NON_TER 220
FT /evidence="ECO:0000313|EMBL:ACR53388.1"
SQ SEQUENCE 220 AA; 24752 MW; B12A0A4B3C83B728 CRC64;
SCMKAAPMKE VSIRGQGSLA YPGLRTQGNL ETLGGPNDAT RGLTSLADTF EHVIEELLDE
QQVIQPSKEN KDADLYSTRV MLSSQVPLEP PLLFLLEEYK NYLDAANMSM RVRRHSDPAR
RGELSVCDST SEWVTAAEKK TAVDMSGATV TVLEKVPVPK GQLKQYFYET KCSSKGYAKE
GCRGIDKRYW NSQCRTTQSF VRALTMDNKK RVGWRFIRID
//
