ID C5H0N0_9SAUR Unreviewed; 211 AA.
AC C5H0N0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Bone morphogenetic protein 2 {ECO:0000313|EMBL:ACR53437.1};
DE Flags: Fragment;
GN Name=BMP2 {ECO:0000313|EMBL:ACR53437.1};
OS Agkistrodon contortrix (Copperhead).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Agkistrodon.
OX NCBI_TaxID=8720 {ECO:0000313|EMBL:ACR53437.1};
RN [1] {ECO:0000313|EMBL:ACR53437.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18570036; DOI=10.1080/10635150802166053;
RA Wiens J.J., Kuczynski C.A., Smith S.A., Mulcahy D.G., Sites J.W.Jr.,
RA Townsend T.M., Reeder T.W.;
RT "Branch lengths, support, and congruence: testing the phylogenomic approach
RT with 20 nuclear loci in snakes.";
RL Syst. Biol. 57:420-431(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; EU402678; ACR53437.1; -; Genomic_DNA.
DR AlphaFoldDB; C5H0N0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF143; BONE MORPHOGENETIC PROTEIN 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 103..211
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 98..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..117
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACR53437.1"
FT NON_TER 211
FT /evidence="ECO:0000313|EMBL:ACR53437.1"
SQ SEQUENCE 211 AA; 24102 MW; D0D5B6CF0F337472 CRC64;
LKPEREATKG PVISLLDTRL VHHNASKWET FDVTPAVMRW IARGQPNLGF VAEVVHLNNA
SNVSKRHVRI SRSLHQDDAS WSRIRPLLVT FGHDGMGHPL HKREKRQAKH KPRKRHKSNC
RRHPLYVDFN DVGWNDWIVA PPGYSAFYCH GDCPFPLADH LNSTNHAIVQ TLVNSVNSKI
PKACCVPTEL SPISMLYLDE NEKVVLKNYQ D
//