ID   C5HHP4_9HIV1            Unreviewed;       199 AA.
AC   C5HHP4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:ACS13503.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:ACS13503.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:ACS13503.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ACS13503.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=F1052xtl16 {ECO:0000313|EMBL:ACS13503.1};
RX   PubMed=19349849; DOI=10.1097/QAD.0b013e328329f964;
RA   Wagner T.A., Tobin N.H., McKernan J.L., Xu M., Melvin A.J., Mohan K.M.,
RA   Learn G.H., Mullins J.I., Frenkel L.M.;
RT   "Increased mutations in Env and Pol suggest greater HIV-1 replication in
RT   sputum-derived viruses compared with blood-derived viruses.";
RL   AIDS 23:923-928(2009).
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DR   EMBL; FJ447128; ACS13503.1; -; Genomic_DNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF5; RIBONUCLEASE H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW   ECO:0000313|EMBL:ACS13503.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          12..199
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACS13503.1"
FT   NON_TER         199
FT                   /evidence="ECO:0000313|EMBL:ACS13503.1"
SQ   SEQUENCE   199 AA;  23170 MW;  320FB8211208C723 CRC64;
     ALTEICTEME KEGKISKIGP ENPYNTPIFA IKKKDSTKWR KLVDFRELNK GTQDFWEVQL
     GIPHPAGLKK KKSVTVLDVG DAYFSVPLYE DFRKYTAFTI PSINNETPGI RYQYNVLPQG
     WKGSPAIFQS SMTKILEPFR KQNPEIVIYQ YMDDLYVGSD LEIGQHRIKI EELREHLLKW
     GFTTPDKKHQ KEPPFLWMG
//