ID C5IKW3_9SPHI Unreviewed; 264 AA.
AC C5IKW3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Aminoglycoside adenyltransferase {ECO:0000313|EMBL:ACS28596.1};
GN Name=aadA2 {ECO:0000313|EMBL:ACS28596.1};
OS Sphingobacterium sp. c49.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Sphingobacterium.
OX NCBI_TaxID=646391 {ECO:0000313|EMBL:ACS28596.1};
RN [1] {ECO:0000313|EMBL:ACS28596.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C49 {ECO:0000313|EMBL:ACS28596.1};
RX PubMed=20400569; DOI=10.1128/AEM.02964-09;
RA Li D., Yu T., Zhang Y., Yang M., Li Z., Liu M., Qi R.;
RT "Antibiotic resistance characteristics of environmental bacteria from an
RT oxytetracycline production wastewater treatment plant and the receiving
RT river.";
RL Appl. Environ. Microbiol. 76:3444-3451(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672};
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DR EMBL; FJ950722; ACS28596.1; -; Genomic_DNA.
DR AlphaFoldDB; C5IKW3; -.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Transferase {ECO:0000313|EMBL:ACS28596.1}.
FT DOMAIN 29..98
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 154..255
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 264 AA; 29705 MW; 6D9F0C113360E620 CRC64;
MEGKAWTIEI PNQLSEVLSV IERHLESTLL AVHLYGSAVD GGLKPYSDID LLVTVAVKLD
ETTRRALLND LMEASAFPGE SETLRAIEVT LVVHDDIIPW RYPAKRELQF GEWQRNDILA
GIFEPAMIDI DLAILLTKAR EHSVALVGPA AEEFFDPVPE QDLFEALRET LKLWNSQPDW
AGDERNVVLT LSRIWYSAIT GKIAPKDVAA DWAIKRLPAQ YQPVLLEAKQ AYLGQKEDHL
ASRADHLEEF IRFVKGEIIK SVGK
//