ID C5KSZ0_PERM5 Unreviewed; 533 AA.
AC C5KSZ0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Metal tolerance protein A2, putative {ECO:0000313|EMBL:EER12340.1};
GN ORFNames=Pmar_PMAR001139 {ECO:0000313|EMBL:EER12340.1};
OS Perkinsus marinus (strain ATCC 50983 / TXsc).
OC Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC Perkinsus.
OX NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN [1] {ECO:0000313|EMBL:EER12340.1, ECO:0000313|Proteomes:UP000007800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG676168; EER12340.1; -; Genomic_DNA.
DR RefSeq; XP_002780545.1; XM_002780499.1.
DR AlphaFoldDB; C5KSZ0; -.
DR EnsemblProtists; EER12340; EER12340; Pmar_PMAR001139.
DR GeneID; 9057387; -.
DR InParanoid; C5KSZ0; -.
DR OrthoDB; 317760at2759; -.
DR Proteomes; UP000007800; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR11562; CATION EFFLUX PROTEIN/ ZINC TRANSPORTER; 1.
DR PANTHER; PTHR11562:SF17; LD05335P; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 386..418
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 419..451
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 180..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 58604 MW; 371B4EB9FD684668 CRC64;
MDHPAAIKGQ GSATNPNLTV VAIPKERIVP APTGHGSNTG EAVEPAKDVQ RRLRKAICLS
MFFMILEIVG GILAHSLAIV TDAAHIMSDV SGFAVSLFAV VLAGKTPTSQ YTYGYRQAEI
LGALFSVMIV WFMTGVLLWE AIQRFITLEE VNGGLMSIMA VAGLVVNVIM MLVLGHHHHH
HHHHHDNHGS HADGHHDHNA RTVEPGHSAT GEGTPSPTPR RLRNLALDAA FIHVLGDLIQ
SVGVVVAAVV IWWEPFNIGS TTDGVSRWKL HIGTLKRSLH ALMQKAPDHV DVRALYKELK
DIPYVDCVDP FRAAVVVLMK VQCWPKLRPW LGAWAFTMRL FSWRYARRTW AIKIGGALWE
GTWKNHEATV RYLIDKGADV NFKDKAGRTP LHEASRYGHT TLVELLVDHR ADIDSLDGAG
ESPLAQAVSC CRHDVVALLT ARGAKLHITD SQGITVQHLA AFTGEPQMAD WLYYRGAWKN
RYAVEHTDNK EEKDANAEEG NMVAAIVPYT QGSEAVQGGD HEELNEGDGE AED
//
