ID   C5LQN6_PERM5            Unreviewed;       688 AA.
AC   C5LQN6;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=VPS10 domain-containing protein {ECO:0000259|SMART:SM00602};
GN   ORFNames=Pmar_PMAR002836 {ECO:0000313|EMBL:EER00771.1};
OS   Perkinsus marinus (strain ATCC 50983 / TXsc).
OC   Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC   Perkinsus.
OX   NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN   [1] {ECO:0000313|EMBL:EER00771.1, ECO:0000313|Proteomes:UP000007800}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA   El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG684654; EER00771.1; -; Genomic_DNA.
DR   RefSeq; XP_002768053.1; XM_002768007.1.
DR   EnsemblProtists; EER00771; EER00771; Pmar_PMAR002836.
DR   GeneID; 9043961; -.
DR   InParanoid; C5LQN6; -.
DR   OMA; LEDYHCA; -.
DR   OrthoDB; 5840at2759; -.
DR   Proteomes; UP000007800; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 2.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..688
FT                   /note="VPS10 domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002955208"
FT   TRANSMEM        614..632
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          52..610
FT                   /note="VPS10"
FT                   /evidence="ECO:0000259|SMART:SM00602"
SQ   SEQUENCE   688 AA;  75423 MW;  F447FF3C0BD878BF CRC64;
     MLFDVSLFVF IFHLCGVSRC KASSASEPKV AIQDVSPDSP IADIVYLGEK QEVILFRTEN
     GHVYRSPDSG LSWQKITDGL GQKSITRTTG VNEMPADSDR IKLIGPHPSD NNVVLLVGVK
     HVHYLSEDSG KSWRFIKHQG LHTYLFHPTD SKSALVSSWS KSCDLHTHER DPDNACQHAL
     YRTSDGGKTF SIVASYVVQF SWGSTKFGSA NRIYFTHHKK KSGDQPHLHG WFSDIDFACT
     DDNGQSVNTL IPGGNKFVMT KDYLFVAKAE EVSGNTVRLE VSANGAKSFA TARIPVALEQ
     HSYTILDAAH GFVMLHVHHG WKNGREVGNI YASDATGTLF SLSLPNVCLN LSEAFAVGNV
     GPFLRYELDD INTYLSRDGG LTWQEVHAGS YSYEIGDHGA LIVMADATRK TNSIVFSWTE
     GSDWYDFDLG AEPFHVTNIL TSDSAASTKF VVYGTRDYQG VLYHLDFSTI LPRICSGYWA
     PDGPSSDYET WIPSAGLVST GSCLLGRITS YVRRKPHAKC FNGEKFERPV FKNNCPCTLE
     DYHCALGFAR TLGETECKPV DVDAVLTPEE MECTSSSAYF ADAYRRVPGD TCEGGFVPAQ
     AQVPCPSSSP LSKAAWVAVG LVVFIIIVLI GLNHASSGPG SNGGFETLRY VKYATLARAG
     KEAVGYMSDN EDDXXTMEML NVGVETSR
//