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Database: UniProt
Entry: C5LX81_PERM5
LinkDB: C5LX81_PERM5
Original site: C5LX81_PERM5 
ID   C5LX81_PERM5            Unreviewed;       820 AA.
AC   C5LX81;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 25.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=Pmar_PMAR016864 {ECO:0000313|EMBL:EEQ98630.1};
OS   Perkinsus marinus (strain ATCC 50983 / TXsc).
OC   Eukaryota; Alveolata; Perkinsea; Perkinsida; Perkinsidae; Perkinsus.
OX   NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN   [1] {ECO:0000313|EMBL:EEQ98630.1, ECO:0000313|Proteomes:UP000007800}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA   El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GG686414; EEQ98630.1; -; Genomic_DNA.
DR   RefSeq; XP_002765913.1; XM_002765867.1.
DR   STRING; 423536.XP_002765913.1; -.
DR   EnsemblProtists; EEQ98630; EEQ98630; Pmar_PMAR016864.
DR   GeneID; 9062338; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; C5LX81; -.
DR   OMA; FLNTFKM; -.
DR   Proteomes; UP000007800; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007800};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    402    426       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    447    474       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    536    555       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    562    583       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    634    654       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    756    779       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   820 AA;  93236 MW;  145D45E616E005C7 CRC64;
     MGILRSELMT HGTVVLPHEY ARNYVDLLGK QTKVMFEDMN SAVMQRPYRK YIQRIEDMER
     MLRVLDSEIA KMPDVTLYKN RIDDFLDHDD EFTLDTLEAE IKRVYEQFIR FRGNNEDLTA
     ELDSATEELN VVQNSLSSGS VAAGTGAALE APLLQGEPTA RGTGRERMGM QFSNIAGVVK
     MEDQESFART VFRATRGNTF TQFTEIPDTR KSVFVIYFQG AAANSYMSAK LHRICGAVGV
     HLYQWPATHD EARVRINELQ SIIADKTHAL AGFDRFIRDE ARGLVEPIRV GGNSRIEEWK
     LFCIKERNIY ATLNLFEGDV TLRCDCWYPS KEEDSIRRVL GESELAASAM LVADIAKPRA
     APPTYTKTNE FTAAFQALVD TYGIPRYQEF NAGVVSIITF PFMFGIMYGD VGHGTLITCF
     ALWALSNAKK WKYSDDGMQQ GLVYARYLLL FMGLFAIYAG CMYNDLLGVG IHWFGTARYE
     DPAEYGHASN YEMKPKAWFD TLNTGEGSGP YPFGIDPSWH GATNELLFMN SLKMKLSVLF
     GVFQMIFGVC IKFGNDAYMR EWIDFIFVAI PQMVFLLGFF GYMDWMIMYK WVTPVTQDPT
     LNGAPSLINT LISFGLGQAD KQPLFLAQPA VQKWLMLAVV ISVPVMLLPK PIIIQIQRSI
     RNKKNNRNAV ANDDVEAQAL ITKESETDEE LEEEGMDEVW IYQMIETIEY VLGCVSHTAS
     YLRLWALSLA HQQLSVVFFQ MIMQGALQST SWASPIFIYC AFAVLFGITL GVLMFMDVLE
     CFLHTWRLHW VEFQSKFYMG DGYSFVPFCH FDIIKDELQA
//
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