ID C5M2M7_CANTT Unreviewed; 291 AA.
AC C5M2M7;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Ribosomal RNA-processing protein 42 {ECO:0000256|ARBA:ARBA00042523};
GN ORFNames=CTRG_00316 {ECO:0000313|EMBL:EER35577.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER35577.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER35577.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the RNase PH family.
CC {ECO:0000256|ARBA:ARBA00006678}.
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DR EMBL; GG692395; EER35577.1; -; Genomic_DNA.
DR RefSeq; XP_002545535.1; XM_002545489.1.
DR AlphaFoldDB; C5M2M7; -.
DR STRING; 294747.C5M2M7; -.
DR EnsemblFungi; CTRG_00316-t43_1; CTRG_00316-t43_1-p1; CTRG_00316.
DR GeneID; 8296162; -.
DR KEGG; ctp:CTRG_00316; -.
DR VEuPathDB; FungiDB:CTRG_00316; -.
DR eggNOG; KOG1612; Eukaryota.
DR HOGENOM; CLU_046570_1_0_1; -.
DR OrthoDB; 2070785at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IEA:EnsemblFungi.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:EnsemblFungi.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IEA:EnsemblFungi.
DR GO; GO:0016075; P:rRNA catabolic process; IEA:EnsemblFungi.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11097:SF8; EXOSOME COMPLEX COMPONENT RRP42; 1.
DR PANTHER; PTHR11097; EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN; 1.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF03725; RNase_PH_C; 1.
DR SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 31..154
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
FT DOMAIN 193..228
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF03725"
SQ SEQUENCE 291 AA; 32650 MW; 828C6E6D5BF5DEBD CRC64;
MVQLSPAERS YLYDSLTQQP IIRPDLRSIH QYRPLVAKTS FLPGSNGSAR IRTGDGSECI
VSVKSKVVLM SQESNLIEVD VDIIGHRDDS NYVSNLKFQL MNLLQQNFPH EILKLTTRYA
FKLYIDCIVI SHTSYPLSLL SLTTYLALKT TRLPLLISDV NDEEIAEQPT FSDDWDNAKL
LQDCLENGKT FQPPIFITIG VIGNNLILDP SIEEEQVLEN GLIVSFYNNK VITPISNTNF
AVNSNNSNFK GLKQSLVVKS IALCNKYCPS IVKALDNLIE EDNDENDGSI F
//
