ID C5M7S0_CANTT Unreviewed; 1418 AA.
AC C5M7S0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Guanine nucleotide exchange factor LTE1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CTRG_01902 {ECO:0000313|EMBL:EER35040.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER35040.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER35040.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
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DR EMBL; GG692396; EER35040.1; -; Genomic_DNA.
DR RefSeq; XP_002547595.1; XM_002547549.1.
DR STRING; 294747.C5M7S0; -.
DR EnsemblFungi; CTRG_01902-t43_1; CTRG_01902-t43_1-p1; CTRG_01902.
DR GeneID; 8301803; -.
DR KEGG; ctp:CTRG_01902; -.
DR VEuPathDB; FungiDB:CTRG_01902; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_004883_0_0_1; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037}.
FT DOMAIN 133..262
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1186..1413
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1059..1093
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..56
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1418 AA; 160289 MW; AB880FBB0B91E5BE CRC64;
MTDEHQQASN LTGEVDKDSS PAETMLECNS DNNFTQDSDN QEFEEQREEE EEQQLSNNLD
DNNSLVNLSN DILSTSTSNH NFQQQQEIAI HAASVHPDFL YNRHNESIFD DEELFPCLPT
QSRDDLVKYD DTNPELINQA TIKALIVHMT SPEIIDYDLI CDFFLTYRLF SNSREVMDLL
LTRLIWALQY LNSPVEDNIK IGKLVLLRTF VVLRHWILNY FIDDFNNDYQ LCDLFAKTMN
SITLESNLVV KHGVEQTEAT INNSIFTSKI LGDLKIHWLK IINEFWLLDL DFDAIMNSNN
AYNYVIPLAT SLNNNKKLSK SNTEISIHTN PSFRRSAMLS LYDSKTHHKT LMFDDENNLQ
AERTQLSINN LFLQHDSSRI SINNKIHQMQ QRKKLVKSPT FSSSFSLPRS SPLSMATSIS
PTKGAPQVKE RRTMKQASRH NHMNIKDSSL DLKKTKTVQH KSHDNQENFP PLTQTTPTKT
KYFNEAGFAT NGHIKLPTSK VAGIVPSTPV KVMDYASTDA QSFMSPKAFA PPQLPSNSSI
FSDHDSLNRR GSIRKLMDSW KKTLVVHKDS ASRMSTATAG TTTTTADQML TSKPSTEDLN
RLITDAINVM DDKKDVGRRV DALSARIIDE LEYLIRNCIR SETSSAIIES HSQFSDQTSN
GNKSNTDSVR TSSGGIASEN EVKNVEEDDQ NVKEPIILKE EDHLKPTEGV PEKDEEDEMD
INDLSDLNIV KIDNLINDSD NVYNVKVPRN ISSSNILEEE EGMEEKQDDS EGSSSFQSPA
SINWNDEDNI NIGDKTPLEE EFDEFNFSTE EPQKKRASQY SEPGFSFQNP NQSTGHSSIS
TPSNITQYDA EVADLGIAMS PHSEKPKRIS FCENANTSLT HNKRLSMWSR NSNGSVFRRD
SIKSYVSYDS AFSIFNEHNS IKYENTEYNG LKKKTGFNNL RIAAGADENQ ITSISRSSSK
SIRYSVLCAL TELPFHELAR LSKQSSADVA DSSIFSSACK SSIRTTNKES FHSTAYTGSS
SNSVAIPGIS SFALKELAAI PDESIQSAED PIQFALHKLE GKSSSKSTLK KKVEEEEEEV
NRMDDTEDIL NEINNAKTVD VISFDDDEEA FDVSATPLTP IKKRINDSTN ITGDDSQGQQ
YQYSQSHSQS RQLDSPSVML DNFSSSLSVD DIMLNNAHIS FVLSYDSEEI AKHMTLIEAD
LSLSLDWKDL IELKWNHLVT GVTSWLQVIL RDFAGVNLVI DRFNLMVNWI ISEVLLSQDE
RDEVIKRFIH IAHHCVQLQN FATTMQIVVA LSSSKIEKYV DDEVDESLKK LCSPLNNFYQ
LRKATNNIQP SKGCIPFVGL YINDLVYNNE RVGKINDRLI NFGKFRTSVA IVKSLSQCIE
WAKNYRFDVQ SELLSKCLYI SSLTEDEMNF CVQFLQKS
//
