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Database: UniProt
Entry: C5M9E0_CANTT
LinkDB: C5M9E0_CANTT
Original site: C5M9E0_CANTT 
ID   C5M9E0_CANTT            Unreviewed;       937 AA.
AC   C5M9E0;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 32.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=CTRG_03012 {ECO:0000313|EMBL:EER34194.1};
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
OC   Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747 {ECO:0000313|EMBL:EER34194.1, ECO:0000313|Proteomes:UP000002037};
RN   [1] {ECO:0000313|EMBL:EER34194.1, ECO:0000313|Proteomes:UP000002037}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L.,
RA   Agrafioti I., Arnaud M.B., Bates S., Brown A.J., Brunke S.,
RA   Costanzo M.C., Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L.,
RA   Hube B., Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R.,
RA   Neiman A.M., Nikolaou E., Quail M.A., Quinn J., Santos M.C.,
RA   Schmitzberger F.F., Sherlock G., Shah P., Silverstein K.A.,
RA   Skrzypek M.S., Soll D., Staggs R., Stansfield I., Stumpf M.P.,
RA   Sudbery P.E., Srikantha T., Zeng Q., Berman J., Berriman M.,
RA   Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GG692397; EER34194.1; -; Genomic_DNA.
DR   RefSeq; XP_002548715.1; XM_002548669.1.
DR   STRING; 294747.XP_002548715.1; -.
DR   EnsemblFungi; EER34194; EER34194; CTRG_03012.
DR   GeneID; 8298497; -.
DR   KEGG; ctp:CTRG_03012; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   KO; K02154; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IEA:EnsemblFungi.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002037};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    492    515       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    536    555       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    621    643       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    650    674       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    714    733       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    844    863       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    875    898       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   937 AA;  107144 MW;  5CF4630FB3EA4371 CRC64;
     MPPIRLTDNT SPKEEINESI FRSAPMTLVQ FYVTIELARD MVGVLGKLGN VQFRDLNSKL
     TPFQRTFVSE LRGIDTMIQQ LDYLHSIMLK QNTIRSDIYA NLQADMKPLP TSSEMDDIKI
     RLDEFYQRIK HLDHSFNNLD KKKLKFVENR SVLNCLNEFH RSNLVGGGYD DLDHHDEHDD
     YDDNEALLNE QRNNNLEIGY EVHHLDDSSF NSMAGTIARD KVPILRNILW RTLRGNLYFH
     DIPLDEEFPV NENSDEMVYK NAFIIYIHGD FLRTRVRRII QSLDGVLFDN AAGGAEARSA
     TLSEINGKID DLNNVVQSTK DQLITELMVF QEVYADYCYI VEREKLIYEA LNKFDEDSTR
     RCLVGEGWIP SYDFEKVRNG LRSLIRSKTR QGATDTDSTE SINLSEGVAT QTALFSVDSD
     QELTGFEIED EEDEEVGSLI AVVNELSTNR VPPTFHKTNK FTAAFQSIID AYGIATYQEV
     NPGLATIITF PFMFSIMFGD VGHGFIVFLV ALYLIKNEVS IGAMRNRDEI FDMAYSGRYI
     ILLMGVFSIY TGFIYNDIFS KSMNLFSSGW KYVVPKDYDV TKGATLVAEK ITGKTYPFGL
     DWAWHGTENN LLFTNSYKMK LSVLMGYTHM NYSLMFSLVN YLFFKSRVDI IGNFIPGFLF
     MQSIFGYLAL TIVYKWSVDW FGINKQPPGL LNMLINMFLS PGTIEEQLYP GQKFVQIVLV
     LIAAICVPWL LIYKPLILKR QNDKAIQLGY SDLHSQRQHS FLIHEEERAL ELQDDELNND
     PPENPFDSDN EEFQFPNDVE PMFHSAAHGE DGEDGFNFGD IVIHQVIHTI EFCLNCVSHT
     ASYLRLWALS LAHAQLSSVL WSMTIQNAFG KTGAVGVIAT VVLFAMWFSL TVCILVLMEG
     TSAMLHSLRL HWVEAMSKFF QGEGYAYEPF TFKSIDI
//
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