ID C5MB07_CANTT Unreviewed; 928 AA.
AC C5MB07;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Kexin {ECO:0000313|EMBL:EER32824.1};
GN ORFNames=CTRG_03249 {ECO:0000313|EMBL:EER32824.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER32824.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER32824.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
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DR EMBL; GG692398; EER32824.1; -; Genomic_DNA.
DR RefSeq; XP_002548952.1; XM_002548906.1.
DR AlphaFoldDB; C5MB07; -.
DR STRING; 294747.C5MB07; -.
DR MEROPS; S08.070; -.
DR EnsemblFungi; CTRG_03249-t43_1; CTRG_03249-t43_1-p1; CTRG_03249.
DR GeneID; 8295971; -.
DR KEGG; ctp:CTRG_03249; -.
DR VEuPathDB; FungiDB:CTRG_03249; -.
DR eggNOG; KOG3525; Eukaryota.
DR HOGENOM; CLU_002976_2_1_1; -.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; IEA:EnsemblFungi.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007323; P:peptide pheromone maturation; IEA:EnsemblFungi.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..928
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005668335"
FT TRANSMEM 779..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 503..643
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 663..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..749
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..765
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..836
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 218
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 256
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 427
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 928 AA; 103853 MW; 757883D2DF6DBD1B CRC64;
MLPIKLLILI LGYLLSPTIQ NEIIPTRDYE SKNYFLVELN TTNSQKPLID FINKYQNHYT
FEHQLPSLDN YYVFSIDKNH PHNSFLGNHN SNGYNLMKRE VGYEEHYDDL ISSVQAIHML
PPKKLSKRIP VPIYEEDLED FTSINQNDDL IARDENNEAT DKAHQKLAQI SSELDIHDPE
FAAQWHLINL KYPGHDVNAT GLWLEDILGQ GIVTALVDDG VDAESEDIKD NFNADGSWDF
NNNGKSPLPR LFDDYHGTRC AGEIAAVKND VCGIGVAWKS QVSGIRILSG PITSADEASA
MIYGLDHNDI YSCSWGPTDN GRVLSEPEVI VKKAMIKGIQ EGRDKKGALY VFASGNGGRF
GDSCNFDGYT NSIYSITVGA IDHKGLHPEY SEACSAVMVV TYSSGSNEHI HTTDIKKKCS
ATHGGTSAAA PLASGIYSLV LSANPDLTWR DVQYISVLSA TPVNEDDGNY QVTALNRKYS
HKYGYGKTDA YQMVHFAKNW KNVKPQAWYY SDVTEVNDSI KTQEDSSKVI KSSITVTEKD
LKVMNVERVE HITVKVNIEA NYRGRVGMRI ISPTGVISDL AAFRRSDASG KGFQNWTFMS
VAHWGESGLG EWKVEVFADD SHGDNVVINF KDWQFRIFGE SIDADKAELY DLEKDYAAVR
RELLEKGDDK PEDKQTTSSS ETTKVETTEG QVGEETSIAN GETTTSQDNS TTSTDKSNET
GTPATSSNVK PSETDSDSEE QNKEGDNKQQ EEEGEEEDET DDGEESDDKT KVKSSDHTGI
YFMSIAVVGF VAVLLLMKFH KTPGSGRRRR RREEYEFDII PGEDYSDSDE EDDQDHDSFD
LGNRNDQRLQ GQGQREYDRR DDEARDRLFD EFNAESLPDH ESDMFKIGDD EEEELNPSSG
EQSSGKGPVD KSQTKVDQKH DSDIDSNK
//
