ID C5MBL4_CANTT Unreviewed; 414 AA.
AC C5MBL4;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Vta1 C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CTRG_03456 {ECO:0000313|EMBL:EER33031.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER33031.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER33031.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Endosome membrane {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004481}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the VTA1 family.
CC {ECO:0000256|ARBA:ARBA00007895}.
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DR EMBL; GG692398; EER33031.1; -; Genomic_DNA.
DR RefSeq; XP_002549159.1; XM_002549113.1.
DR AlphaFoldDB; C5MBL4; -.
DR STRING; 294747.C5MBL4; -.
DR EnsemblFungi; CTRG_03456-t43_1; CTRG_03456-t43_1-p1; CTRG_03456.
DR GeneID; 8297980; -.
DR KEGG; ctp:CTRG_03456; -.
DR VEuPathDB; FungiDB:CTRG_03456; -.
DR eggNOG; KOG0917; Eukaryota.
DR HOGENOM; CLU_679712_0_0_1; -.
DR OrthoDB; 5491267at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.420; Immunoglobulin FC, subunit C; 1.
DR Gene3D; 1.25.40.270; Vacuolar protein sorting-associated protein vta1; 1.
DR InterPro; IPR044538; Vta1-like.
DR InterPro; IPR039431; Vta1/CALS_N.
DR InterPro; IPR023175; Vta1/CALS_N_sf.
DR InterPro; IPR041212; Vta1_C.
DR PANTHER; PTHR46009; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG; 1.
DR PANTHER; PTHR46009:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG; 1.
DR Pfam; PF04652; Vta1; 1.
DR Pfam; PF18097; Vta1_C; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 17..182
FT /note="Vta1/callose synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04652"
FT DOMAIN 370..406
FT /note="Vta1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18097"
FT REGION 203..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..228
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 47449 MW; C005BA3D807C854F CRC64;
MTITTASIPE ELKTNKSITP YIIRSIELTQ ANPVVSYYCK IYVLEYILTN KLHTTSKEIE
TFTIELLDDT ESIKKDETDE NLHKILNDKQ LSFNLVFSFS YKLFNSCLEG LSEITQDNKL
QLIGKFKATL NFLNVLEVFK NSEINWIQIT GGKANNWDEF DKLNKEKIKL LKFQLSRILK
NQVEFKDELK DEDLEKELDQ ELQELDEEQV GNDNDNDDDN DDNEEDGGND KEINLPGAPN
ELPKFIDEND DQGHPELPSA PRFIDESTET DQPEDDNDTV KLPGVPHISP DVQEEEDESM
KLPGAPKYLP DDDITHINKS STIHVFTPSD KSTNKPDPSI RKPSSSSSST HKHHAPLTKE
NIKQILNRDD TITQVQKHAK FAQSALQFED FKEAEKQLTQ GLELLRVLRE QEDE
//
