ID C5MC01_CANTT Unreviewed; 1222 AA.
AC C5MC01;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=CTRG_03593 {ECO:0000313|EMBL:EER33168.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER33168.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER33168.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; GG692398; EER33168.1; -; Genomic_DNA.
DR RefSeq; XP_002549296.1; XM_002549250.1.
DR AlphaFoldDB; C5MC01; -.
DR STRING; 294747.C5MC01; -.
DR EnsemblFungi; CTRG_03593-t43_1; CTRG_03593-t43_1-p1; CTRG_03593.
DR GeneID; 8297449; -.
DR KEGG; ctp:CTRG_03593; -.
DR VEuPathDB; FungiDB:CTRG_03593; -.
DR eggNOG; KOG0217; Eukaryota.
DR HOGENOM; CLU_002472_1_0_1; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0032301; C:MutSalpha complex; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:EnsemblFungi.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0000400; F:four-way junction DNA binding; IEA:EnsemblFungi.
DR GO; GO:0032137; F:guanine/thymine mispair binding; IEA:EnsemblFungi.
DR GO; GO:0032138; F:single base insertion or deletion binding; IEA:EnsemblFungi.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:EnsemblFungi.
DR GO; GO:0043570; P:maintenance of DNA repeat elements; IEA:EnsemblFungi.
DR GO; GO:0000710; P:meiotic mismatch repair; IEA:EnsemblFungi.
DR GO; GO:0043111; P:replication fork arrest; IEA:EnsemblFungi.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037}.
FT DOMAIN 1049..1065
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..212
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1222 AA; 137340 MW; B289AF6380724BA7 CRC64;
MGKSSTPAKS SPKVGSSGGS GKKQTSLMDF FKPASAKSKS KSQPSPLSSS PLKSKSTSKP
FISSDKENEE DEEIMNHKDN TLSTSQPPAD QFEKPKANAT APSPHPAKQV EPKKKPLTDR
TSMLNSSPVA SSRRRPKVNY AESDDDEEEE EIRGSRKKRR IVQDDSDDDD DAHEEFKPPA
SDNDDDDDDD MSDFVVDDDA DDDDDMEPAS EDEDEPVPKK KKTKKSASPA AKITTPSKSN
SVSASSVLSK FNSSSSYQSS PATTTPKKQP TKSATPTKKS FEKENEERYE WLVNIRDAEK
RTVDDPEYDP RTLYIPQSAW SKFTNFEKQY WGIKSKMWNT VVFFQKGKFY ELYENDAIIA
NTKFDLKIAG GGRANMKLAG IPEMSFEYWA KEFISHGYKV AKVDQKESLL AKEMRGGTTK
EEKIIKRELT GILTGGTLTD LNMITNDMST YCLSIKEEEN EDGTKVFGVA FVDTATSELN
FIELQDDAEC TKLDTLITQV KPKEVICEKG NLCQIANKIL KFCAHSENQI WNILNPITEF
WDYDNTIEEL VKSKYYEAED LDDYSKYPEI LVTYKDNHPL AFSAFGGLLY YLKLLKLDSS
IMSLGNIHEY QISKNANNHM ILDGITLNNL EILHNTADGS DKGTLFKLLN RATTSFGKRL
LQQWILHPLY KIDEINARYD SVDFFMNDGL ELRSAIQDVL FTLPDLERLL ARVHAKTLKF
RDFLRVIESF EAIAKLSTKL KDFANVECGI LYNYLSSFPH EMSELIDQWE DSFDREQAKS
DVIIPASGVD EQFDESQTLL GDLESQLNQK LKEYKRTYKS QSICYRDSGK EIYLIEVPVK
LNVPQDWQQM GATSKVKRYW SPEVKKLARK LMEQRELHKQ VCDTLKNRMF EKFDAHYQTW
MGVIRSIGNI DCLLALTKAS ESMGFPSCRP SFIDAAKGCV DFKELRHPCF EGTKEFIPND
VQLGGSNPHF GLLTGANAAG KSTLMRTTAL AVMLSQIGCH IPAESAKLTP VDRIMTRLGA
NDNIMQGKST FFVELSETKK ILSNATPKSL VILDELGRGG SSSDGFSIAE SVLHHLATHL
QSLGFFATHY GTLGLSFKTH PQIKQLRMGI VVDNNSRNIT FLYKLEEGTA PRSFGMNVAA
MCGIPEEIVD NAERAANEYE QTSKLKKLAE ESDVHDISLG LQSDFVWWGT GKIDDLGKDM
ISYDEAIKKS ALDNIAKMID SL
//
