ID C5MCW9_CANTT Unreviewed; 322 AA.
AC C5MCW9;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Protein BIG1 {ECO:0000256|ARBA:ARBA00022089};
GN ORFNames=CTRG_04070 {ECO:0000313|EMBL:EER32399.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER32399.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER32399.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}.
CC -!- SIMILARITY: Belongs to the BIG1 family.
CC {ECO:0000256|ARBA:ARBA00008203}.
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DR EMBL; GG692399; EER32399.1; -; Genomic_DNA.
DR RefSeq; XP_002549773.1; XM_002549727.1.
DR AlphaFoldDB; C5MCW9; -.
DR STRING; 294747.C5MCW9; -.
DR EnsemblFungi; CTRG_04070-t43_1; CTRG_04070-t43_1-p1; CTRG_04070.
DR GeneID; 8297048; -.
DR KEGG; ctp:CTRG_04070; -.
DR VEuPathDB; FungiDB:CTRG_04070; -.
DR eggNOG; ENOG502RXHV; Eukaryota.
DR HOGENOM; CLU_067894_0_0_1; -.
DR OrthoDB; 1977668at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR037654; Big1.
DR PANTHER; PTHR28285; PROTEIN BIG1; 1.
DR PANTHER; PTHR28285:SF2; PROTEIN BIG1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..322
FT /note="Protein BIG1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002955566"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 322 AA; 37562 MW; F6A344998059D781 CRC64;
MRVLYLLALF LPLVTCRVTP LLVASHKLVR GLKQEINPSN LAVHNVTSVT NMLKKLITDC
SSDAYLIINL PGLTYQDLTT VNKDQWPFLR KYLYMASTLV GLPRVEANLD LDFLEQYIIN
TCEAETVNVF QSHEEVVDYY DVRTRVIRMD LAPLSENDED IRTSQIYDCD QLIRKILRKL
PSPHYSIIFT SLNPGVIHPI PKHIMQQDPD SFEIFSDILN DPINNQEVEK NDRFHKVEPD
LNPIRHSNDK YIRNKKKDEI HLFDYELWTK NEKLVTTIFV MVVSLFMMKI VSFLKTLKQK
FLEYNQNKAK KGIITSTDKK KD
//
