ID C5ME80_CANTT Unreviewed; 393 AA.
AC C5ME80;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Cns1/TTC4 wheel domain-containing protein {ECO:0000259|Pfam:PF18972};
GN ORFNames=CTRG_04372 {ECO:0000313|EMBL:EER31590.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER31590.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER31590.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the TTC4 family.
CC {ECO:0000256|ARBA:ARBA00023602}.
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DR EMBL; GG692400; EER31590.1; -; Genomic_DNA.
DR RefSeq; XP_002550075.1; XM_002550029.1.
DR AlphaFoldDB; C5ME80; -.
DR STRING; 294747.C5ME80; -.
DR EnsemblFungi; CTRG_04372-t43_1; CTRG_04372-t43_1-p1; CTRG_04372.
DR GeneID; 8296793; -.
DR KEGG; ctp:CTRG_04372; -.
DR VEuPathDB; FungiDB:CTRG_04372; -.
DR eggNOG; KOG0551; Eukaryota.
DR HOGENOM; CLU_040446_0_0_1; -.
DR OrthoDB; 854582at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR GO; GO:0030544; F:Hsp70 protein binding; IEA:EnsemblFungi.
DR GO; GO:0051879; F:Hsp90 protein binding; IEA:EnsemblFungi.
DR GO; GO:0043022; F:ribosome binding; IEA:EnsemblFungi.
DR GO; GO:0042026; P:protein refolding; IEA:EnsemblFungi.
DR CDD; cd21381; CTWD_TTC4; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR044059; Csn1/TTC4_wheel.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46035; TETRATRICOPEPTIDE REPEAT PROTEIN 4; 1.
DR PANTHER; PTHR46035:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 4; 1.
DR Pfam; PF18972; Wheel; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 165..198
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 266..383
FT /note="Cns1/TTC4 wheel"
FT /evidence="ECO:0000259|Pfam:PF18972"
FT COILED 201..231
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 393 AA; 45046 MW; 60685A92C7213B32 CRC64;
MSDTTSTQAS EETPKEYVSE WERRRYVPKA GEPALPPQLA EYSNKTTDEV IEELNRLPFF
MTKLDESDGD GGENINLEAL KSLAYEGDPD EIATNFKNQG NDCYKYKKYK DAIIYYTKGL
EVDCQVPAID SALYLNRAAC NLELKNYRRC IEDCKKVLMI DEKNIKACFR SGKAFFAIEK
FDEAIKIIEY GLSVDPENKD LLKLLKTVKD KQQLLADIEA KKKQEEEQQR LENIVLENSI
KLRHIEIIKS SSPPDALKEA KIRLEDPKDY QSQLIFPAMI LYPTTDEFDF IGEISELSTP
LELLEIVLDR PSEWFADPKH KDFNVKKLEC FMETESGGLV KVGKKLEVNN ALMNDKPKAP
LFDNALRLYV VPKPDVAKWT SEWNKDSALA ARK
//
