ID C5MHU2_CANTT Unreviewed; 615 AA.
AC C5MHU2;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
GN ORFNames=CTRG_05635 {ECO:0000313|EMBL:EER30639.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER30639.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER30639.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC subfamily. {ECO:0000256|ARBA:ARBA00006457}.
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DR EMBL; GG692403; EER30639.1; -; Genomic_DNA.
DR RefSeq; XP_002551337.1; XM_002551291.1.
DR AlphaFoldDB; C5MHU2; -.
DR STRING; 294747.C5MHU2; -.
DR EnsemblFungi; CTRG_05635-t43_1; CTRG_05635-t43_1-p1; CTRG_05635.
DR GeneID; 8300849; -.
DR KEGG; ctp:CTRG_05635; -.
DR VEuPathDB; FungiDB:CTRG_05635; -.
DR eggNOG; KOG1342; Eukaryota.
DR HOGENOM; CLU_007727_0_2_1; -.
DR OrthoDB; 1327607at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:1902494; C:catalytic complex; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0004407; F:histone deacetylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR CDD; cd10004; RPD3-like; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR003084; His_deacetylse_1.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF13; HISTONE DEACETYLASE HDAC1; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR PRINTS; PR01271; HISDACETLASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037}.
FT DOMAIN 37..324
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 409..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 615 AA; 69722 MW; 847FCA752F724C52 CRC64;
MYVDLPFDEL KVDPNQKKRI AYFYDADIGN YAYGAGHPMK PHRIRMAHSL IMNYGLYKKM
EIYRAKPATK QEMCQFHTDE YIDFISRVNP DNLDLFTKEQ IKFNVGDDCP VFDGLFEYCG
ISGGGSMEGA ARLNRGKCDI AINYAGGLHH AKKSEASGFC YLNDIVLGII ELLRYHPRVL
YIDIDVHHGD GVEEAFYTTD RVMTCSFHKY GEFFPGTGEL RDIGVGKGKY HAVNVPLRDG
IDDATYKSVF EPLITKIIEW YQPSAIVLQC GGDSLSGDRL GCFNLSMNGH ANCVNFVKSF
NIPLMVLGGG GYTMRNVART WAYESGLLNN VKLPNELPYN EYYEYYGPDY KLDVRPSNMF
NQNSPEFLDK ILLNIISNLE NTKHAPSVQM NEVPNDPEDL GDVEEDTAEA MDTKGGSEMN
RDSQIQPDNE FYEDDDKDKG EKDISNNKDE DAMDIDKPEE AKPEESKPEE AKPEEAKPEE
AKPEEAKSEE AKPEESKHEE TKPVEAKHEE SKPEESKPEE SKPEEQPAPV EEPKSIEEVK
TADESKPSEE TKPETITLEE SKSQEPRAEE EPKPEEPKES KPEDAKPIDE DHPMEDANKP
TEEELKEIEE LNKEE
//
