ID C5NSP0_MCFA Unreviewed; 194 AA.
AC C5NSP0;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
OS Mosquito cell fusing agent (CFA flavivirus).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Flavivirus.
OX NCBI_TaxID=31658 {ECO:0000313|EMBL:BAH83686.1};
OH NCBI_TaxID=7158; Aedes.
RN [1] {ECO:0000313|EMBL:BAH83686.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Surabaya-10 {ECO:0000313|EMBL:BAH83686.1};
RX PubMed=19580982; DOI=10.1016/j.virol.2009.06.025;
RA Hoshino K., Isawa H., Tsuda Y., Sawabe K., Kobayashi M.;
RT "Isolation and characterization of a new insect flavivirus from Aedes
RT albopictus and Aedes flavopictus mosquitoes in Japan.";
RL Virology 391:119-129(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-
CC diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15;
CC Evidence={ECO:0000256|ARBA:ARBA00001491};
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DR EMBL; AB488427; BAH83686.1; -; Genomic_RNA.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011492; Flavi_DEAD.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF07652; Flavi_DEAD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Virion {ECO:0000256|ARBA:ARBA00022804};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 1..117
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAH83686.1"
FT NON_TER 194
FT /evidence="ECO:0000313|EMBL:BAH83686.1"
SQ SEQUENCE 194 AA; 20791 MW; 89E731D48B2E4329 CRC64;
RTVILTPTRV VMAEVVEALK NSGMRSDKNL SYCTRNLITV ACHATFTKFV LSHGAKKVRV
ALIIMDECHF MDPMSIAARG IMEHLHSQGT KLIYLSATPP GHAPDTGSNY AISDQAISFP
TWLSPAWIGK VQKSVGAKKT ILFVPSHNQA NTLASAIPGS VPLHRANFST NYAQAGDAAT
ALVISTDISE MGAN
//
