ID C5P0H1_COCP7 Unreviewed; 843 AA.
AC C5P0H1;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Elongation factor 2 {ECO:0000256|ARBA:ARBA00017891};
GN ORFNames=CPC735_068610 {ECO:0000313|EMBL:EER29179.1};
OS Coccidioides posadasii (strain C735) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=222929 {ECO:0000313|EMBL:EER29179.1, ECO:0000313|Proteomes:UP000009084};
RN [1] {ECO:0000313|EMBL:EER29179.1, ECO:0000313|Proteomes:UP000009084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EER29179.1}.
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DR EMBL; ACFW01000009; EER29179.1; -; Genomic_DNA.
DR RefSeq; XP_003071324.1; XM_003071278.1.
DR AlphaFoldDB; C5P0H1; -.
DR GeneID; 9696818; -.
DR KEGG; cpw:CPC735_068610; -.
DR VEuPathDB; FungiDB:CPC735_068610; -.
DR HOGENOM; CLU_002794_11_2_1; -.
DR OrthoDB; 166721at2759; -.
DR Proteomes; UP000009084; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01681; aeEF2_snRNP_like_IV; 1.
DR CDD; cd04096; eEF2_snRNP_like_C; 1.
DR CDD; cd01885; EF2; 1.
DR CDD; cd16261; EF2_snRNP_III; 1.
DR CDD; cd03700; EF2_snRNP_like_II; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF10; ELONGATION FACTOR 2; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:EER29179.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 17..254
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 843 AA; 93490 MW; 3A420FE7FC399555 CRC64;
MVNFTVEEIR QLMDRPANIR NMSVIAHVDH GKSTLTDSMV QRAGIISAAK AGEARFTDTR
QDEQDRCITI KSTAISLYAH LSDPEDIKDI PQKVDGNEFL INLIDSPGHV DFSSEVTAAL
RVTDGALVVV DCVSGVCVQT ETVLRQALSE RIKPVCIINK VDRALLELQV SKEDLYQSFA
RTIESVNVII ATYFDPALGD VQVYPYKGTV AFGSGLHGWA FTVRQFAVKY AKKFGVDRNK
MMERLWGDNY FNPKTKKWTK VGEHEGKQLE RAFNQFILDP IFKIFNAITH SKKDEISVLL
EKLEIKLSSD EKDLEGKPLL KVVMKKFLPA ADALLEMMVL HLPSPVTAQK YRAETLYEGP
PDDEVCIGIR DCDPKAPLML YVSKMVPTSD KGRFYAFGRV FAGTVRSGLK VRIQGPNYTP
GKKEDLHIKA IQRTILMMGR FIEPIEDVPA GNIVGLVGVD QFLLKSGTLT TCETAHNLKV
MKFSVSPVVQ RSVEVKNAND LPKLVEGLKR LSKSDPCVLT YISESGEHVI AGAGELHLEI
CLKDLEEDHA GVPLRVSDPV VSYRETVGAE SSITALSKSP NKHNRLYVKA EPLAEEVSNA
IEAGKISPRD DFKARARVLA DEFGWDVTDA RKIWCFGPDT TGANLVVDQT KAVQYLNEIK
DSVVSGFQWA SREGPIAEEP MRSIRFNILD VTLHADAIHR GGGQIIPTAR RVIYAATLLA
EPGILEPVFL VEIQVPEQAM GGIYGVLTRR RGHVFSEEQR PGTPLFTVKA YLPVNESFGF
SADLRSATSG QAFPQSVFDH WQILPGGSPL DPTTKPGQIV QEMRKRKGIK EVVPGVENYY
DKL
//
