ID   C5P0Z2_COCP7            Unreviewed;       862 AA.
AC   C5P0Z2;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Calpain family cysteine protease containing protein {ECO:0000313|EMBL:EER29350.1};
DE            EC=3.4.22.- {ECO:0000313|EMBL:EER29350.1};
GN   ORFNames=CPC735_070320 {ECO:0000313|EMBL:EER29350.1};
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929 {ECO:0000313|EMBL:EER29350.1, ECO:0000313|Proteomes:UP000009084};
RN   [1] {ECO:0000313|EMBL:EER29350.1, ECO:0000313|Proteomes:UP000009084}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SIMILARITY: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.
CC       {ECO:0000256|ARBA:ARBA00010193}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EER29350.1}.
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DR   EMBL; ACFW01000009; EER29350.1; -; Genomic_DNA.
DR   RefSeq; XP_003071495.1; XM_003071449.1.
DR   AlphaFoldDB; C5P0Z2; -.
DR   MEROPS; C02.008; -.
DR   GeneID; 9696989; -.
DR   KEGG; cpw:CPC735_070320; -.
DR   VEuPathDB; FungiDB:CPC735_070320; -.
DR   HOGENOM; CLU_006770_1_0_1; -.
DR   OrthoDB; 230045at2759; -.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00044; CysPc; 1.
DR   Gene3D; 2.60.120.380; -; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR   InterPro; IPR022684; Calpain_cysteine_protease.
DR   InterPro; IPR022682; Calpain_domain_III.
DR   InterPro; IPR022683; Calpain_III.
DR   InterPro; IPR036213; Calpain_III_sf.
DR   InterPro; IPR007330; MIT_dom.
DR   InterPro; IPR036181; MIT_dom_sf.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR   PANTHER; PTHR46143; CALPAIN-7; 1.
DR   PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR   Pfam; PF01067; Calpain_III; 1.
DR   Pfam; PF00648; Peptidase_C2; 1.
DR   PRINTS; PR00704; CALPAIN.
DR   SMART; SM00720; calpain_III; 1.
DR   SMART; SM00230; CysPc; 1.
DR   SMART; SM00745; MIT; 1.
DR   SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF116846; MIT domain; 1.
DR   PROSITE; PS50203; CALPAIN_CAT; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00239};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU00239,
KW   ECO:0000313|EMBL:EER29350.1};
KW   Thiol protease {ECO:0000256|PROSITE-ProRule:PRU00239}.
FT   DOMAIN          117..444
FT                   /note="Calpain catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50203"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          73..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        195
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        364
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        384
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
SQ   SEQUENCE   862 AA;  95932 MW;  AAA92762F146BF3E CRC64;
     MTRLREFKSK ALQAERDVST STTHTEALEA AIRAAENYMH ALRLASDPRE KKALDAKCKE
     YITQAEHLKH LKEGSGVQSN ASASARAEVR QRREPVSTRT LSNREQIILL ENSKLNGFVF
     PPWSAQPGPE EFELDEEDEL FTDCSELGLS ASQQQMFDGW KRPSEIFTEA RKEDRDILMM
     SKNPMDLVQD VTTDCSVVAS LCAGVSQDVR GYPQLAQTIK MYPCDKDTSI PQLSPSGKYI
     FRMHFNGCYR KVVIDDRLPS SKTSRSLFVV DRNSPTVIWP ALVEKAYLKV RGGYDFPGSN
     SGTDMWILTG WIPEQIFLHH DEVTCDQIWD RLFNSFLAAD VLLTIGTGKL TSREEREVGL
     ISSHDYAILD MRESNGKRQF LIKNPWAGGA KWKGVSGASA VSALQEIEFE FSSPQRSPLS
     PGTFWMDCDE VFQNFENLYL NWNPRLFRYR QDIHFRWDLS SAPPVPGCFT ENPQFAITSK
     SGGKLWLLLN KHFKSGETSD AVNQLLDPEV DEPGFISIYV FNKRGQRVYL SDGAIHRSPY
     VDSPNTLVRL DMPPNTTFTA VVAEQSLHRS IQSFSLSGFS TGPLSVCPAT EKYAHVRKVQ
     AAWTLSTAGG NAESERYPLN PQFKLKVSEK CDVAVLLETD NGDLATHVKI FWSKGERVAE
     VRLRDIVCDS GDYRRGFALA EADAMTKGTY TIVCSTFAPD QLGKFTLRVS STHPCEVTPL
     PREGAGRLLM SSGLGVLSPG IDRILAPITV SRLSRLKLVA RRKGSWIGHR TVAPSPILMT
     LELGQGPYKE ILAASGDGDF SDLVTGARIE SVDLQPELGL RGGVWLVVER VGGPGGQVED
     HIEVEILSEE RVEIGRWGVG DG
//