ID CHI1_COCP7 Reviewed; 427 AA.
AC C5P230; P54196; Q00432; Q00435; Q400W4; Q400W5; Q400W6; Q9C0M7;
AC Q9C2W1;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 1.
DT 01-MAY-2013, entry version 25.
DE RecName: Full=Endochitinase 1;
DE EC=3.2.1.14;
DE AltName: Full=CiX1;
DE AltName: Full=Complement-fixation antigen;
DE Short=CF-AG;
DE Short=CF-antigen;
DE Flags: Precursor;
GN Name=CTS1; ORFNames=CPC735_036390;
OS Coccidioides posadasii (strain C735) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; mitosporic Onygenales; Coccidioides.
OX NCBI_TaxID=222929;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C735;
RX PubMed=8566773; DOI=10.1016/0378-1119(95)00654-0;
RA Pishko E.J., Kirkland T.N., Cole G.T.;
RT "Isolation and characterization of two chitinase-encoding genes (cts1,
RT cts2) from the fungus Coccidioides immitis.";
RL Gene 167:173-177(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C735;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens
RT Coccidioides and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- CATALYTIC ACTIVITY: Random hydrolysis of N-acetyl-beta-D-
CC glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. Chitinase
CC class II subfamily.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA92643.1; Type=Erroneous gene model prediction;
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DR EMBL; L41663; AAA92643.1; ALT_SEQ; Genomic_DNA.
DR EMBL; ACFW01000012; EER28933.1; -; Genomic_DNA.
DR RefSeq; XP_003071078.1; XM_003071032.1.
DR UniGene; Cpo.4627; -.
DR ProteinModelPortal; C5P230; -.
DR GeneID; 9696573; -.
DR KEGG; cpw:CPC735_036390; -.
DR KO; K01183; -.
DR GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR GO; GO:0004568; F:chitinase activity; IEA:EC.
DR GO; GO:0006032; P:chitin catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.80; -; 2.
DR InterPro; IPR011583; Chitinase_II.
DR InterPro; IPR001223; Glyco_hydro18cat.
DR InterPro; IPR001579; Glyco_hydro_18_chit_AS.
DR InterPro; IPR013781; Glyco_hydro_catalytic_dom.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR Pfam; PF00704; Glyco_hydro_18; 1.
DR SMART; SM00636; Glyco_18; 1.
DR SUPFAM; SSF51445; Glyco_hydro_cat; 1.
DR PROSITE; PS01095; CHITINASE_18; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Chitin degradation; Chitin-binding;
KW Complete proteome; Glycoprotein; Glycosidase; Hydrolase;
KW Polysaccharide degradation; Signal.
FT SIGNAL 1 17 By similarity.
FT CHAIN 18 427 Endochitinase 1.
FT /FTId=PRO_0000387962.
FT ACT_SITE 171 171 Proton donor (By similarity).
FT SITE 169 169 Transition state stabilizer (By
FT similarity).
FT CARBOHYD 387 387 N-linked (GlcNAc...) (Potential).
FT CONFLICT 103 103 K -> N (in Ref. 1; AAA92643).
FT CONFLICT 109 109 T -> I (in Ref. 1; AAA92643).
SQ SEQUENCE 427 AA; 47400 MW; 7DDA4A82DD67A21B CRC64;
MRFLIGALLT LQTLVQASSM SSMPNSYPVP EAPAEGGFRS VVYFVNWAIY GRGHNPQDLK
ADQFTHILYA FANIRPSGEV YLSDTWADTD KHYPGDKWDE PGKNVYGCTK QMYLLKKNNR
NLKTLLSIGG WTYSPNFKTP ASTEEGRKKF ADTSLKLMKD LGFDGIDIDW EYPEDEKQAN
DFVLLLKACR EALDAYSAKH PNGKKFLLTI ASPAGPQNYN KLKLAEMDKY LDFWNLMAYD
FSGSWDKVSG HMSNVFPSTT KPESTPFSSD KAVKDYIKAG VPANKIVLGM PLYGRAFAST
DGIGTSFNGV GGGSWENGVW DYKDMPQQGA QVTELEDIAA SYSYDKNKRY LISYDTVKIA
GKKAEYITKN GMGGGMWWES SSDKTGNESL VGTVVNGLGG TGKLEQRENE LSYPESVYDN
LKNGMPS
//
