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Database: UniProt
Entry: C5P230
LinkDB: C5P230
Original site: C5P230 
ID   CHI1_COCP7              Reviewed;         427 AA.
AC   C5P230; P54196; Q00432; Q00435; Q400W4; Q400W5; Q400W6; Q9C0M7;
AC   Q9C2W1;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   09-JUL-2014, entry version 29.
DE   RecName: Full=Endochitinase 1;
DE            EC=3.2.1.14;
DE   AltName: Full=CiX1;
DE   AltName: Full=Complement-fixation antigen;
DE            Short=CF-AG;
DE            Short=CF-antigen;
DE   Flags: Precursor;
GN   Name=CTS1; ORFNames=CPC735_036390;
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; mitosporic Onygenales; Coccidioides.
OX   NCBI_TaxID=222929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C735;
RX   PubMed=8566773; DOI=10.1016/0378-1119(95)00654-0;
RA   Pishko E.J., Kirkland T.N., Cole G.T.;
RT   "Isolation and characterization of two chitinase-encoding genes (cts1,
RT   cts2) from the fungus Coccidioides immitis.";
RL   Gene 167:173-177(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA   Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA   Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA   Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA   Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens
RT   Coccidioides and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- CATALYTIC ACTIVITY: Random hydrolysis of N-acetyl-beta-D-
CC       glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. Chitinase
CC       class V subfamily.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA92643.1; Type=Erroneous gene model prediction;
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DR   EMBL; L41663; AAA92643.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; ACFW01000012; EER28933.1; -; Genomic_DNA.
DR   RefSeq; XP_003071078.1; XM_003071032.1.
DR   UniGene; Cpo.4627; -.
DR   ProteinModelPortal; C5P230; -.
DR   GeneID; 9696573; -.
DR   KEGG; cpw:CPC735_036390; -.
DR   KO; K01183; -.
DR   OrthoDB; EOG7WQ826; -.
DR   GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR   GO; GO:0004568; F:chitinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006032; P:chitin catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.10; -; 1.
DR   Gene3D; 3.20.20.80; -; 2.
DR   InterPro; IPR011583; Chitinase_II.
DR   InterPro; IPR029070; Chitinase_insertion.
DR   InterPro; IPR001223; Glyco_hydro18cat.
DR   InterPro; IPR001579; Glyco_hydro_18_chit_AS.
DR   InterPro; IPR013781; Glyco_hydro_catalytic_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   Pfam; PF00704; Glyco_hydro_18; 1.
DR   SMART; SM00636; Glyco_18; 1.
DR   SUPFAM; SSF51445; SSF51445; 2.
DR   SUPFAM; SSF54556; SSF54556; 1.
DR   PROSITE; PS01095; CHITINASE_18; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Chitin degradation; Chitin-binding;
KW   Complete proteome; Glycoprotein; Glycosidase; Hydrolase;
KW   Polysaccharide degradation; Signal.
FT   SIGNAL        1     17       By similarity.
FT   CHAIN        18    427       Endochitinase 1.
FT                                /FTId=PRO_0000387962.
FT   ACT_SITE    171    171       Proton donor (By similarity).
FT   SITE        169    169       Transition state stabilizer (By
FT                                similarity).
FT   CARBOHYD    387    387       N-linked (GlcNAc...) (Potential).
FT   CONFLICT    103    103       K -> N (in Ref. 1; AAA92643).
FT   CONFLICT    109    109       T -> I (in Ref. 1; AAA92643).
SQ   SEQUENCE   427 AA;  47400 MW;  7DDA4A82DD67A21B CRC64;
     MRFLIGALLT LQTLVQASSM SSMPNSYPVP EAPAEGGFRS VVYFVNWAIY GRGHNPQDLK
     ADQFTHILYA FANIRPSGEV YLSDTWADTD KHYPGDKWDE PGKNVYGCTK QMYLLKKNNR
     NLKTLLSIGG WTYSPNFKTP ASTEEGRKKF ADTSLKLMKD LGFDGIDIDW EYPEDEKQAN
     DFVLLLKACR EALDAYSAKH PNGKKFLLTI ASPAGPQNYN KLKLAEMDKY LDFWNLMAYD
     FSGSWDKVSG HMSNVFPSTT KPESTPFSSD KAVKDYIKAG VPANKIVLGM PLYGRAFAST
     DGIGTSFNGV GGGSWENGVW DYKDMPQQGA QVTELEDIAA SYSYDKNKRY LISYDTVKIA
     GKKAEYITKN GMGGGMWWES SSDKTGNESL VGTVVNGLGG TGKLEQRENE LSYPESVYDN
     LKNGMPS
//
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