ID   C5P354_COCP7            Unreviewed;       414 AA.
AC   C5P354;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=3 beta-hydroxysteroid dehydrogenase, putative {ECO:0000313|EMBL:EER28742.1};
GN   ORFNames=CPC735_040060 {ECO:0000313|EMBL:EER28742.1};
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929 {ECO:0000313|EMBL:EER28742.1, ECO:0000313|Proteomes:UP000009084};
RN   [1] {ECO:0000313|EMBL:EER28742.1, ECO:0000313|Proteomes:UP000009084}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EER28742.1}.
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DR   EMBL; ACFW01000014; EER28742.1; -; Genomic_DNA.
DR   RefSeq; XP_003070887.1; XM_003070841.1.
DR   AlphaFoldDB; C5P354; -.
DR   GeneID; 9696381; -.
DR   KEGG; cpw:CPC735_040060; -.
DR   VEuPathDB; FungiDB:CPC735_040060; -.
DR   HOGENOM; CLU_007383_6_8_1; -.
DR   OrthoDB; 1133at2759; -.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
FT   DOMAIN          13..323
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   414 AA;  46313 MW;  3995B2CAF2FDD8A4 CRC64;
     MAPERKIELG SVLVVGGCGF LGTHIVDHLL NFPSEDSGST SRITGANGEP DKRFSYPQLR
     GRYPIYKNTK VSVADLRTTN NRLPGADYYD ADVLSIESLL EVFRAVKPDV VIDTVSLMLE
     GNKELIYNVN VNGTRNLLEV AGGMRGDWGG KCKAFVYTSS SSVVHDTTSD LIHVDERWPK
     ITGKLQQEYY TETKAIAEDM VLDFNGTSPS GMLTVAIRPA GIYGERDTTL TFKMVEHAAK
     SSQRILNFQL GDNNNLFDFT YVGNIAYSHM LAAELLLETK KRTEAGAAAP LDYERVDGEA
     FNITNDSPVY FWDMARTIWA LMDRYVEPHQ VFELSESTLT VVGGILETVF GLFGKKPRLT
     RREVRYSCMS RYYSCNKAKV RLGYRPIVRL DEGVARAVGY LLEKDSNLRA KKEL
//