ID   C5P6M0_COCP7            Unreviewed;       732 AA.
AC   C5P6M0;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   SubName: Full=GTP-binding protein, putative {ECO:0000313|EMBL:EER27070.1};
GN   ORFNames=CPC735_024060 {ECO:0000313|EMBL:EER27070.1};
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929 {ECO:0000313|EMBL:EER27070.1, ECO:0000313|Proteomes:UP000009084};
RN   [1] {ECO:0000313|EMBL:EER27070.1, ECO:0000313|Proteomes:UP000009084}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EER27070.1}.
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DR   EMBL; ACFW01000025; EER27070.1; -; Genomic_DNA.
DR   RefSeq; XP_003069215.1; XM_003069169.1.
DR   AlphaFoldDB; C5P6M0; -.
DR   GeneID; 9694710; -.
DR   KEGG; cpw:CPC735_024060; -.
DR   VEuPathDB; FungiDB:CPC735_024060; -.
DR   HOGENOM; CLU_378545_0_0_1; -.
DR   OrthoDB; 325175at2759; -.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   CDD; cd04938; TGS_Obg; 1.
DR   CDD; cd01899; Ygr210; 1.
DR   Gene3D; 1.10.8.470; -; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR031167; G_OBG.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013646; YGR210-like_G4.
DR   PANTHER; PTHR23305; OBG GTPASE FAMILY; 1.
DR   PANTHER; PTHR23305:SF1; OBG-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   Pfam; PF08438; YGR210-like_G4; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51710; G_OBG; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          394..590
FT                   /note="OBG-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51710"
SQ   SEQUENCE   732 AA;  80200 MW;  D6DB415C8DA12C39 CRC64;
     MKQMFSITKG RSKHTFLSTA MNISSVYDYN APFPADEVYD LIKRSWSTDP TQSNDPVIRQ
     ISEKIGNASA KNSSFQLGGV HKVENSIAQA NFEFLNPEGT PGKVIFSLFR ISVVNITLVS
     NRGRTYGTNC YKQGSQNNTG ARFFGEIDTS AVLIISGTLG DGSSNISSKA FNQQAFEWLA
     KNENRLDNLV LSRGYIMAID PALVTLEISR VRPAMSYLQV LLVILPVVLA VITWGLLRFF
     AASHYSSSLL ANLYATTNVR DTDTSADPQY IHTIPDIDLV RKDGKVLMAT SGGVFTHCEE
     QSNVASVNVA NQKLEYPKSS YPPNNNSLMP RDPLIGLVGK PSSGKSTTLN SFTTIDPQRA
     IGYLQIDCAC QRHNLTEKCK PNYGSCHEGR RSVPIELLDV AGLVPGAHEG KGLGNKFLDD
     LRHADALIHV VDVSGTTDAE GKATRGYDPS QDIIWLKSEI VRWILGNLME KWGSIKRRHV
     AVKATPVETL QTQFSGYGAT SKIVARCLDR LDLKEPLQDW SDETIAQVVV AFIDEKFPTV
     LALNKIDHPD ADKNINKIAK VQDSQSIVLC SAISEVFLRK LAKQGYVKYV EGSEFVDTRE
     DLIEMGDPDG GGLKEMDDKL KNRVENLKDL VLYRFGSTGV VQVLSRAAEL LGLVPVFPVR
     NIHNFTSGSG GGNAVFRDCV LVKKNSTVAD VARKVMGDAP IAYVEGVGGI RVSEDEVVSV
     GKHDILSFKV GR
//