ID C5PCX2_COCP7 Unreviewed; 741 AA.
AC C5PCX2;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 1 {ECO:0000256|RuleBase:RU364059};
DE AltName: Full=Mediator complex subunit 1 {ECO:0000256|RuleBase:RU364059};
GN ORFNames=CPC735_015310 {ECO:0000313|EMBL:EER24933.1};
OS Coccidioides posadasii (strain C735) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=222929 {ECO:0000313|EMBL:EER24933.1, ECO:0000313|Proteomes:UP000009084};
RN [1] {ECO:0000313|EMBL:EER24933.1, ECO:0000313|Proteomes:UP000009084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364059}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364059}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC {ECO:0000256|ARBA:ARBA00006210, ECO:0000256|RuleBase:RU364059}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EER24933.1}.
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DR EMBL; ACFW01000043; EER24933.1; -; Genomic_DNA.
DR RefSeq; XP_003067078.1; XM_003067032.1.
DR AlphaFoldDB; C5PCX2; -.
DR GeneID; 9692549; -.
DR KEGG; cpw:CPC735_015310; -.
DR VEuPathDB; FungiDB:CPC735_015310; -.
DR HOGENOM; CLU_008378_2_0_1; -.
DR OrthoDB; 2102567at2759; -.
DR Proteomes; UP000009084; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR InterPro; IPR019680; Mediator_Med1.
DR PANTHER; PTHR35041; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1; 1.
DR PANTHER; PTHR35041:SF4; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1; 1.
DR Pfam; PF10744; Med1; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU364059};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364059};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364059};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364059}.
FT DOMAIN 136..554
FT /note="Mediator complex subunit Med1"
FT /evidence="ECO:0000259|Pfam:PF10744"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 741 AA; 82255 MW; 7D12932F52578C50 CRC64;
MATPFSKSNL GATPTQFTSS PHPSAVPMGR PLSHKSPSMK TPSASGQGHQ NYPSTSSHQY
PTPLPITSAA IEDVAVFSSP SALLALGLGG ITPSPAANDA LGGQGINEGD LHSMAIPSLG
ITGPKDIEDE KRKRIDEVLQ LLRTRVAGRG VCREGIERLG KLEGLECMWQ DNDLSIAGNS
LDLEVEFEPG QEIVKNVTLR YATPDAPEGE RRVEASEVLK RNLMQGPGEQ EGGHWKSMAE
FHENLRRLAR LDQLSREINC FEAVEGIYEC LRRIWDEEKK HGTRQIHLDH ICKGWIGKPS
MHGGKHVGLM LRYWVDQRRM FEAKQVPPSN AMDTDLPAQD DEEVPDKANF YSAAIECETG
YPSLRVSKEW VSADVFTEIR NEDGGDNELE IRMINWTEPP PTLVSPLSNN PDSVALEPTI
LSSTAPNIRF VARLEPPVDM PIFAAVEIYR AIGANMMQES KTTTYDSLVV PSQGDSNFIE
FEGRQVMQKR EISTFGADGK PVKQQHTYTF NTFEQVPGRT IRDIPFSHPR QLADVLPILR
QYAFISSLLR RIFSDSQTAS RSDTQRTPGE KSVPQLFQES RPNGYFISNV NPTECRLNSL
LRSGRNNGFK PPPTAISTPP ANEVRVDISL RTPMSLPPTV LLVFNINEDN QMRSSDSAPL
LTRIASRQVM IGADIGLNGE INISHTSGIL PSNATDYTSN EKCEDEKRKL RSQIARVLET
CEDLGMLVEW VLKWIRKHTD G
//
