ID C5PES2_COCP7 Unreviewed; 1059 AA.
AC C5PES2;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 22-FEB-2023, entry version 55.
DE SubName: Full=RhoGAP domain containing protein {ECO:0000313|EMBL:EER24592.1};
GN ORFNames=CPC735_059620 {ECO:0000313|EMBL:EER24592.1};
OS Coccidioides posadasii (strain C735) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=222929 {ECO:0000313|EMBL:EER24592.1, ECO:0000313|Proteomes:UP000009084};
RN [1] {ECO:0000313|EMBL:EER24592.1, ECO:0000313|Proteomes:UP000009084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EER24592.1}.
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DR EMBL; ACFW01000049; EER24592.1; -; Genomic_DNA.
DR RefSeq; XP_003066737.1; XM_003066691.1.
DR AlphaFoldDB; C5PES2; -.
DR GeneID; 9692207; -.
DR KEGG; cpw:CPC735_059620; -.
DR VEuPathDB; FungiDB:CPC735_059620; -.
DR HOGENOM; CLU_004568_2_0_1; -.
DR OrthoDB; 25175at2759; -.
DR Proteomes; UP000009084; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04396; RhoGAP_fSAC7_BAG7; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR PANTHER; PTHR15228:SF25; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
FT DOMAIN 78..288
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..800
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1059 AA; 113672 MW; 1B019146DA305DF7 CRC64;
MANRQQSSGS PSARAPPAAS GAASSSSPDV PSAPSRRDLA SWWKQFKRNT KKDETAPQSA
GIFGVPLNVS IKYANVAISL TGDDGKSFVY GYVPIVVAKC GVFLKEKATD VEGIFRLSGS
AKRIKDLQEI FNSPDRYGKG LDWTGYTVHD AANILRRYLN QLPEPIVPLD FYERFRDPLR
RGHPQTQVDG EDEQSDNTAA LTREEAVLTY QRLIKELPPL NRQLLLYILD LLTVFASKSD
LNRMTAGNLA AIFQPGLLSH PNHDMSPQEY KLSQDVLVFL IENQDNFLFG MTGTAADEQT
VKEMQEGIYA HPAKSGIRRS ASNASGGADS LRKYETLRRN VSVSSKTSKQ SGGNVTSPAT
PRSVSSFGVH RSNTVPSKRP PGLSPTAFNR SPRPSNPPTG GLSPSASPLL ASRSQSRVSS
IEAMNEAKNT RPDLSLDTNP PAAKADAEAR PQQNVPGPII SKPVVTPNKE RKLSSLFAWS
SPPEDGRQPN RLRKKRRIPG SASESAQSST QSLHDNSYDV GSSPPPLVRG LSGTDLDQSH
VSTPRILTTS SLATAMTPLA SQSGSEERSG PQVATESILK STLSRTPSPS LHYVTDQSDL
EHTEENTDKK EKRRSWRFHR SSRRAGEPVS LSISPPAPLG SHAGAGFSTS SLASSNIHNQ
IMANDTTRVN KESSTSTLLS QSSDVVSGTS VTSPPVTKDN GDEERKSFFS KFKAKVSHVK
DGMKDKESDL GRSQSPPTSD HERSSSRTSL SFFNRDAKAN RAPPADATRD QRHSEAQDKP
TAPTTMSPPS SLPPGPSQIQ IASPPSTMPQ DPTTPDVVTV LPKVEEEPSL PDTITDQGVE
SKQPCRPPTQ APVQESTQDT PEVPTGDTPL PLDPVKATSE VPLESPSQGV TGTSGEVAPE
QHINVQIESS VEAPTGESAE LVSKQTTEAP AEAPPKCSTA APTQSTAETK MELPSTTPTR
IPIETSLERS TDVPTQPTTE GKTRVSSTMT TELPMEKLPE PSTDAPLQPP ARVLAEVAAK
IALRDASNQA TSIQAAPPQS QDESETKTQL ETKSQPGSS
//
