ID C5PFQ5_COCP7 Unreviewed; 1268 AA.
AC C5PFQ5;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 08-NOV-2023, entry version 71.
DE SubName: Full=GTPase-activator protein for Ras-like GTPase containing protein {ECO:0000313|EMBL:EER23358.1};
GN ORFNames=CPC735_047280 {ECO:0000313|EMBL:EER23358.1};
OS Coccidioides posadasii (strain C735) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=222929 {ECO:0000313|EMBL:EER23358.1, ECO:0000313|Proteomes:UP000009084};
RN [1] {ECO:0000313|EMBL:EER23358.1, ECO:0000313|Proteomes:UP000009084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EER23358.1}.
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DR EMBL; ACFW01000049; EER23358.1; -; Genomic_DNA.
DR RefSeq; XP_003065503.1; XM_003065457.1.
DR AlphaFoldDB; C5PFQ5; -.
DR GeneID; 9690973; -.
DR KEGG; cpw:CPC735_047280; -.
DR VEuPathDB; FungiDB:CPC735_047280; -.
DR HOGENOM; CLU_003244_0_1_1; -.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000009084; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd00030; C2; 1.
DR CDD; cd05137; RasGAP_CLA2_BUD2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF60; GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT DOMAIN 507..675
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 730..966
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1203..1233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1240..1254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1268 AA; 142806 MW; 245669DA7953BC71 CRC64;
MEPDRRNGFR RDPDRQDYHR RPIERRPSKK SSSKDRHGVV YPESFRDATI RTVTPDSMSD
NANNSPMSDA EYMSATTTSP HATLRAKHRE RRQESAPYFS AGDDEDLGLG PKSLRARSRT
TLDDQRSEIS QSLLSRTRTR LGSINVASQS SKGSEDSVSS IGYPSIIQSP TQRQRLSKAP
SGGASLVASS SRLSSYGSPL SNSDSSKILQ LMKTTCGRMH GILSFRASGS TSWTSGYCAI
NVASGSLIYQ AKGEPAAAKT LIPDLRGCRV RTLYDTEIQG SYLSVSAHSS TVGIHLRPHV
IETFDSWLAA LLCWQPIRPK GVQNKMTKPQ SVAIGNHRFP ERRRNSESTI QKEAAIIKVG
QMLLWDRQTA SGLLPPPTPK RISTFKQQRA LSPSWRKVSC SLQENGHMKI FTETDVTLIA
FVQLSQLSRC AIQQLEPSVL HDEFCIAIYP QYSVHAGGDQ LTRPIYLSLE SRILFEVWFV
LLRAFTIPEL YGPEQPPPND DPARNHSLAV SNATSTADMF RIERLLSIRI IEAKMFTSVK
DSVEVTKTKK PVKPHLSQMK IRASGDYYAE VLLDGEVRAK TAAKHDTSTP FWREDFTFHD
LPPVLSNASI MVKTLNSTQK DWTLISRAPY SFEDVSSDPL SIVGDVEITS QDATYGRIDL
RLEDLERGSG PEKWWPILDD HDQPVGEMLM RVQLDETVVL ISKEYEAMSE LLHSFSNGLT
VNLAHLVPPE LRQLSETFLD IFQVSGQAGE WIMALVEDEI DGIHKDSTAS RLRYTSRSRI
HSNDSYESTQ EREALVRDLG RSATVEANLL FRGNSLLTKS LDMHMRRLGK EYLEETIGAG
LRDIDESDPD CEIDPNKVSR HEDLERNWRN LILLTSSMWK SIANSASRCP AELRHIFRHI
RACAEDRYGD FLRSVAYSSV SGFLFLRFFC PAILNPKLFG LLKEHPRQRA QRTLTLIAKA
LQGLANLATF GNKEPWMEPM NKFLLSHRSE FKDFVDSICS IPAERGAQIV NPSYATPIQI
LNRLPPTSRE GFPSLPFLID NAKSFAFLVR LWLESAPPNL MVMSDIDETV LQFHKLCLQI
QQRTKDCLNK AEQAERPNGN LEVKWEELVE QFEKSSTFYE ESSSKANTPS VETAMSNVAA
MSGNNRNSIG YFSRPPFQHR STDMSNASED AEDDTRSHAI STNWDPGRPK FTVPKYSEAR
ESADSSHNSS TYSLEYPEQP KIRQSSVSKE SSSKYRLFDL VGNSRRKARE KESQQFLPSD
LGPRDEYI
//