ID C5PG74_COCP7 Unreviewed; 887 AA.
AC C5PG74;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Probable E3 ubiquitin ligase complex SCF subunit sconB {ECO:0000256|ARBA:ARBA00015819};
DE AltName: Full=Sulfur controller B {ECO:0000256|ARBA:ARBA00032113};
DE AltName: Full=Sulfur metabolite repression control protein B {ECO:0000256|ARBA:ARBA00030034};
GN ORFNames=CPC735_048970 {ECO:0000313|EMBL:EER23527.1};
OS Coccidioides posadasii (strain C735) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=222929 {ECO:0000313|EMBL:EER23527.1, ECO:0000313|Proteomes:UP000009084};
RN [1] {ECO:0000313|EMBL:EER23527.1, ECO:0000313|Proteomes:UP000009084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Component of the SCF(sconB) E3 ubiquitin ligase complex
CC involved in the regulation of sulfur metabolite repression, probably by
CC mediating the inactivation or degradation of the metR transcription
CC factor. {ECO:0000256|ARBA:ARBA00002730}.
CC -!- PATHWAY: Protein modification. {ECO:0000256|ARBA:ARBA00043952}.
CC -!- SUBUNIT: Component of the SCF(sconB) E3 ubiquitin ligase complex.
CC {ECO:0000256|ARBA:ARBA00011725}.
CC -!- SIMILARITY: Belongs to the WD repeat MET30/SCONB/SCON-2 family.
CC {ECO:0000256|ARBA:ARBA00007968}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EER23527.1}.
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DR EMBL; ACFW01000049; EER23527.1; -; Genomic_DNA.
DR RefSeq; XP_003065672.1; XM_003065626.1.
DR AlphaFoldDB; C5PG74; -.
DR GeneID; 9691142; -.
DR KEGG; cpw:CPC735_048970; -.
DR VEuPathDB; FungiDB:CPC735_048970; -.
DR HOGENOM; CLU_000288_103_0_1; -.
DR OrthoDB; 337075at2759; -.
DR Proteomes; UP000009084; Unassembled WGS sequence.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22847:SF723; E3 UBIQUITIN LIGASE COMPLEX SCF SUBUNIT SCONB-RELATED; 1.
DR PANTHER; PTHR22847; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 100..146
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REPEAT 305..344
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 346..389
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 391..421
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 479..518
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 519..558
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..826
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 887 AA; 98414 MW; 6B4AEA9E2D8671D7 CRC64;
MDHDPTDPAG APPLGKLQSD KYKGGLGAPS NSFRLDEGYS DETKSEAGND GPLGNGFALP
PWLLSHTEPV RADLAFALLS TLRTSTIANI VERLTPLLHM DPVQKLPPEI TAEIFSYLDP
TTLLTASLAS RAWRDRIQDS LLWRKLYLQE GWKVNMEEVR TFQRQRAESM QSALRKVRMR
RSDTEFGQPL QKRRVLPGRT NSTGSSVSMV EGDASNSAMC RPADAGGDYE MQDVGNIDNS
AGCPPLDRDL PLTPYKEAFL SPALCADDPT RLNWVYLYRQ RRILEDNWLN GRFKNFQLPH
PLYPWEAHRE CIYAIQFSGN WLVSSSRDRT IRIWNLETRR LRYPPLLGHK GSVLCLQFDA
SEEEDIIISG SSDRNVIIWR FSTGEKLQVL SNAHLDSVLS LRFDKRYLVT CSKDKLIKVW
NRQELSPSDE DYPKYFTGVG VRYPPYIVDT SSMSPSTLEA QIANEHIKSL QPYSLLMTLD
GHGAAVNSIQ IDKNEIVSAS GDRLIKVWDI HSGSCLKTLV GHQKGIACVQ FDSKRIISGS
NDLTVRIYDH ASGAEVACLL AHEDLVRTLQ AGFGDPPGSE ETMRLEAMAV DHDYWEAQRR
GDIRHETGRR RVSRMRSTGS RRPQDIMALG AKIPPGGGGS RWARIVSGSY DETIIIWKRD
KEGKWVVGQR LRQTDAARAS SAIDDSMATE FLTQTFGANL PGIHRHLQAA THHPQSNAFA
GPSQSAAAVA PSSAQAGASS SIPQPSITAQ NAFANQLLQP HSQPQSSAQV SPNAQQAPIP
IPQNQATQIP TTGQVQPTAL QPQPHQPQPQ PQHPALQPPV GPHPTAPTQT NNPGQVPPHH
HATARIFKLQ FDARKLICAS QDHVIVGWDF ANGDKYLEEV CRFFESL
//
