ID C5PJ58_COCP7 Unreviewed; 374 AA.
AC C5PJ58;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=tRNA N(3)-methylcytidine methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
DE EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR037755};
GN ORFNames=CPC735_020350 {ECO:0000313|EMBL:EER23007.1};
OS Coccidioides posadasii (strain C735) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=222929 {ECO:0000313|EMBL:EER23007.1, ECO:0000313|Proteomes:UP000009084};
RN [1] {ECO:0000313|EMBL:EER23007.1, ECO:0000313|Proteomes:UP000009084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase.
CC {ECO:0000256|PIRNR:PIRNR037755}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC {ECO:0000256|ARBA:ARBA00009725, ECO:0000256|PIRNR:PIRNR037755}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EER23007.1}.
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DR EMBL; ACFW01000051; EER23007.1; -; Genomic_DNA.
DR RefSeq; XP_003065152.1; XM_003065106.1.
DR AlphaFoldDB; C5PJ58; -.
DR GeneID; 9690621; -.
DR KEGG; cpw:CPC735_020350; -.
DR VEuPathDB; FungiDB:CPC735_020350; -.
DR HOGENOM; CLU_029724_1_0_1; -.
DR OrthoDB; 5471626at2759; -.
DR Proteomes; UP000009084; Unassembled WGS sequence.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProt.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR026113; METTL2/6/8-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22809:SF11; METHYLTRANSFERASE-LIKE PROTEIN; 1.
DR PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR PIRSF; PIRSF037755; Mettl2_prd; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
KW Transferase {ECO:0000256|PIRNR:PIRNR037755}.
FT DOMAIN 141..246
FT /note="Methyltransferase type 12"
FT /evidence="ECO:0000259|Pfam:PF08242"
FT REGION 19..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 374 AA; 43098 MW; C931775DA5DCA699 CRC64;
MSPLPLEGFD DYATVAQLVQ PPQVPRHRSH DPSNNQKRSD PFQFGSRYLE EGDDVFEFNA
WDHVETDEDY KQYAQLQIAK QRESPVSDFN RQRFNSDPAK WWDLFYKNNT GNFFKNRKWL
QQEFPVLAEV TKADAGPKLV LEVGAGAGNT AFPILANNSN EQLKVHACDY SKKAIEVIRE
NEKYDERYIR ADVWDVTAEG ESSLPPGLGE ESVDVVVMVF IFSALAPEQW ERAVSNIYRV
LKPGGQILFR DYGRGDLAQV RFKKERYMAE NFYVRGDGTR VYFFDRDELA HIWGEWCPQR
GLPKNELATA ESEINEGAES AGFEVLDLAV DRRLIVNRKR KLKMYRCWIQ GRFRKIELTS
TGESNGNQAG QLEN
//
