ID C5QQZ3_9STAP Unreviewed; 498 AA.
AC C5QQZ3;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000256|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000256|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000256|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000256|HAMAP-Rule:MF_00212,
GN ECO:0000313|EMBL:EES40759.1};
GN ORFNames=HMPREF0793_1649 {ECO:0000313|EMBL:EES40759.1};
OS Staphylococcus caprae M23864:W1.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=525378 {ECO:0000313|EMBL:EES40759.1, ECO:0000313|Proteomes:UP000003152};
RN [1] {ECO:0000313|EMBL:EES40759.1, ECO:0000313|Proteomes:UP000003152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M23864:W1 {ECO:0000313|EMBL:EES40759.1,
RC ECO:0000313|Proteomes:UP000003152};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001139, ECO:0000256|HAMAP-
CC Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005012, ECO:0000256|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000256|HAMAP-
CC Rule:MF_00212}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EES40759.1}.
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DR EMBL; ACJB01000054; EES40759.1; -; Genomic_DNA.
DR RefSeq; WP_002441949.1; NZ_GG696773.1.
DR AlphaFoldDB; C5QQZ3; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_9; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000003152; Unassembled WGS sequence.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR NCBIfam; NF040844; Lac_Quin_Ox_NO; 1.
DR NCBIfam; TIGR01320; mal_quin_oxido; 1.
DR PANTHER; PTHR43104; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43104:SF2; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|HAMAP-Rule:MF_00212};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630, ECO:0000256|HAMAP-
KW Rule:MF_00212};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, ECO:0000256|HAMAP-
KW Rule:MF_00212};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532, ECO:0000256|HAMAP-
KW Rule:MF_00212}.
SQ SEQUENCE 498 AA; 56410 MW; D51A41D2B435525C CRC64;
MNTKESKTVV IIGAGVLSTT FGSMLKEIEP NWNIKLYERL DRPGIESSNE RHNAGTGHAA
LCELNYTVRK PDGSIDIEKA KEINEQFEIS KQFWSHLVKN KSISNPKEFI QPLPHISFVR
GKNNVQFLKD RYYAMKDFPM FDNIEYTEDI EEMRKWIPLM MKGHNSSDIM AASKINEGTD
VNFGELTRKM AKNIEQHPNA NVQYNHEVID FNHRKDGKWE VKVRQRNSGD VQTELADYVF
IGAGGGAIPL LQKTGIPESK NLGGFPITGQ FLICTNPDTI AKHDAKVYGK EPKGTPPMTV
PHLDTRYIDG ERTLLFGPFA SVGPKFLKNG SNLDLFKSIK PYNITTLLSS AVKNLPLIKY
SFDQILMTKE GCMNHLRTFY PEARDEDWQL YTAGKRVQVI KDTPEHGKGY IQFGTEVVNS
KDHSIIALLG ESPGASTSVS VALEVLEKNF SEYESKWTPK IKKMIPSYGQ SLVNDIGLMR
TIRKQTSKDL ELNYYENK
//
